| Rank | Player (age), + - HOFer, Bold - Active | Cmp | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (38) | 5,377 | 1991-2007 | 2TM |
| 2. | Vinny Testaverde (44) | 3,787 | 1987-2007 | 7TM |
| 3. | Peyton Manning (31) | 3,468 | 1998-2007 | clt |
| 4. | Kerry Collins (35) | 2,918 | 1995-2007 | 5TM |
| 5. | Steve McNair (34) | 2,733 | 1995-2007 | 2TM |
| 6. | Brad Johnson (39) | 2,627 | 1994-2007 | 4TM |
| 7. | Jon Kitna (35) | 2,394 | 1997-2007 | 3TM |
| 8. | Tom Brady (30) | 2,294 | 2000-2007 | nwe |
| 9. | Trent Green (37) | 2,228 | 1997-2007 | 4TM |
| 10. | Donovan McNabb (31) | 2,189 | 1999-2007 | phi |
| 11. | Jeff Garcia (37) | 2,020 | 1999-2007 | 5TM |
| 12. | Kurt Warner (36) | 1,926 | 1998-2007 | 3TM |
| 13. | Drew Brees (28) | 1,921 | 2001-2007 | 2TM |
| 14. | Matt Hasselbeck (32) | 1,904 | 1999-2007 | 2TM |
| 15. | Daunte Culpepper (30) | 1,867 | 1999-2007 | 3TM |
| 16. | Trent Dilfer (35) | 1,759 | 1994-2007 | 5TM |
| 17. | Brian Griese (32) | 1,642 | 1998-2007 | 4TM |
| 18. | Marc Bulger (30) | 1,578 | 2002-2007 | ram |
| 19. | Gus Frerotte (36) | 1,521 | 1994-2007 | 7TM |
| 20. | Joey Harrington (29) | 1,424 | 2002-2007 | 3TM |
| 21. | David Carr (28) | 1,316 | 2002-2007 | 2TM |
| 22. | Carson Palmer (28) | 1,305 | 2004-2007 | cin |
| 23. | Chad Pennington (31) | 1,259 | 2000-2007 | nyj |
| 24. | Jake Delhomme (32) | 1,206 | 1999-2007 | 2TM |
| 25. | Eli Manning (26) | 987 | 2004-2007 | nyg |
| 26. | Ben Roethlisberger (25) | 908 | 2004-2007 | pit |
| 27. | Byron Leftwich (27) | 821 | 2003-2007 | 2TM |
| 28. | Charlie Batch (33) | 818 | 1998-2007 | 2TM |
| 29. | Kyle Boller (26) | 746 | 2003-2007 | rav |
| 30. | Josh McCown (28) | 609 | 2002-2007 | 3TM |
| 31. | Philip Rivers (26) | 578 | 2004-2007 | sdg |
| 32. | Kelly Holcomb (34) | 565 | 1997-2007 | 4TM |
| 33. | Tony Romo (27) | 555 | 2004-2007 | dal |
| 34. | Damon Huard (34) | 524 | 1998-2007 | 3TM |
| 35. | David Garrard (29) | 521 | 2002-2007 | jax |
| 36. | Patrick Ramsey (28) | 509 | 2002-2007 | 3TM |
| 37. | J.P. Losman (26) | 495 | 2004-2007 | buf |
| 38. | Rex Grossman (27) | 489 | 2003-2007 | chi |
| 39. | Alex Smith (23) | 435 | 2005-2007 | sfo |
| 40. | Tim Rattay (30) | 432 | 2000-2007 | 3TM |
| 41. | Vince Young (24) | 422 | 2006-2007 | oti |
| 42. | Chris Weinke (35) | 386 | 2001-2007 | 2TM |
| 43. | Jay Cutler (24) | 378 | 2006-2007 | den |
| 44. | A.J. Feeley (30) | 372 | 2001-2007 | 2TM |
| 45. | Todd Collins (36) | 369 | 1995-2007 | 3TM |
| 46. | Derek Anderson (24) | 364 | 2006-2007 | cle |
| 47. | Jason Campbell (26) | 360 | 2006-2007 | was |
| 48. | Jamie Martin (37) | 355 | 1996-2007 | 3TM |
| 49. | Charlie Frye (26) | 354 | 2005-2007 | 2TM |
| 50. | Anthony Wright (31) | 332 | 2000-2007 | 4TM |