| Rank | Player (age), + - HOFer, Bold - Active | Cmp | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (40) | 5,936 | 1991-2009 | 4TM |
| 2. | Peyton Manning (33) | 4,110 | 1998-2009 | clt |
| 3. | Kerry Collins (37) | 3,268 | 1995-2009 | 5TM |
| 4. | Mark Brunell (39) | 2,738 | 1994-2009 | 4TM |
| 5. | Donovan McNabb (33) | 2,688 | 1999-2009 | phi |
| 6. | Kurt Warner (38) | 2,578 | 1998-2009 | 3TM |
| 7. | Tom Brady (32) | 2,562 | 2000-2009 | nwe |
| 8. | Drew Brees (30) | 2,552 | 2001-2009 | 2TM |
| 9. | Jeff Garcia (39) | 2,264 | 1999-2009 | 5TM |
| 10. | Matt Hasselbeck (34) | 2,182 | 1999-2009 | 2TM |
| 11. | Marc Bulger (32) | 1,969 | 2002-2009 | ram |
| 12. | Daunte Culpepper (32) | 1,962 | 1999-2009 | 4TM |
| 13. | Chad Pennington (33) | 1,631 | 2000-2009 | 2TM |
| 14. | Jake Delhomme (34) | 1,616 | 1999-2009 | 2TM |
| 15. | Carson Palmer (30) | 1,572 | 2004-2009 | cin |
| 16. | Eli Manning (28) | 1,466 | 2004-2009 | nyg |
| 17. | Ben Roethlisberger (27) | 1,426 | 2004-2009 | pit |
| 18. | David Carr (30) | 1,340 | 2002-2009 | 3TM |
| 19. | Philip Rivers (28) | 1,093 | 2004-2009 | sdg |
| 20. | David Garrard (31) | 1,055 | 2002-2009 | jax |
| 21. | Tony Romo (29) | 1,029 | 2004-2009 | dal |
| 22. | Jay Cutler (26) | 997 | 2006-2009 | 2TM |
| 23. | Michael Vick (29) | 933 | 2001-2009 | 2TM |
| 24. | Byron Leftwich (29) | 900 | 2003-2009 | 4TM |
| 25. | Jason Campbell (28) | 867 | 2006-2009 | was |
| 26. | Charlie Batch (35) | 819 | 1998-2009 | 2TM |
| 27. | Kyle Boller (28) | 795 | 2003-2009 | 2TM |
| 28. | Matt Schaub (28) | 747 | 2004-2009 | 2TM |
| 29. | Kyle Orton (27) | 701 | 2005-2009 | 2TM |
| 30. | Josh McCown (30) | 610 | 2002-2009 | 4TM |
| 31. | Aaron Rodgers (26) | 597 | 2005-2009 | gnb |
| 32. | Derek Anderson (26) | 572 | 2006-2009 | cle |
| 33. | Alex Smith (25) | 530 | 2005-2009 | sfo |
| 34. | Matt Cassel (27) | 508 | 2005-2009 | 2TM |
| 35. | Trent Edwards (26) | 505 | 2007-2009 | buf |
| 36. | Vince Young (26) | 488 | 2006-2009 | oti |
| 37. | Joe Flacco (24) | 476 | 2008-2009 | rav |
| 38. | Matt Ryan (24) | 469 | 2008-2009 | atl |
| 39. | Todd Collins (38) | 379 | 1995-2009 | 3TM |
| 40. | Ryan Fitzpatrick (27) | 353 | 2005-2009 | 3TM |
| 41. | Seneca Wallace (29) | 331 | 2005-2009 | sea |
| 42. | JaMarcus Russell (24) | 330 | 2007-2009 | rai |
| 43. | Shaun Hill (29) | 322 | 2005-2009 | 2TM |
| 44. | Billy Volek (33) | 316 | 2001-2009 | 2TM |
| Tarvaris Jackson (26) | 316 | 2006-2009 | min | |
| 46. | Matt Leinart (26) | 306 | 2006-2009 | crd |
| 47. | Chris Simms (29) | 297 | 2004-2009 | 3TM |
| 48. | Tyler Thigpen (25) | 232 | 2007-2009 | 2TM |
| 49. | Bruce Gradkowski (26) | 231 | 2006-2009 | 3TM |
| 50. | Chris Redman (32) | 195 | 2000-2009 | 2TM |