| Rank | Player (age), + - HOFer, Bold - Active | Int% | Years | Teams |
|---|---|---|---|---|
| 1. | Aaron Rodgers (29) | 1.7% | 2005-2012 | gnb |
| 2. | Tom Brady (35) | 2.1% | 2000-2012 | nwe |
| 3. | Joe Flacco (27) | 2.2% | 2008-2012 | rav |
| 4. | Sam Bradford (25) | 2.3% | 2010-2012 | ram |
| Matt Ryan (27) | 2.3% | 2008-2012 | atl | |
| 6. | Jason Campbell (31) | 2.4% | 2006-2012 | 3TM |
| Shaun Hill (32) | 2.4% | 2005-2012 | 3TM | |
| 8. | Matt Schaub (31) | 2.5% | 2004-2012 | 2TM |
| 9. | Kyle Orton (30) | 2.6% | 2005-2012 | 4TM |
| Philip Rivers (31) | 2.6% | 2004-2012 | sdg | |
| Byron Leftwich (32) | 2.6% | 2003-2012 | 4TM | |
| 12. | Peyton Manning (36) | 2.7% | 1998-2012 | 2TM |
| Drew Brees (33) | 2.7% | 2001-2012 | 2TM | |
| 14. | Andy Dalton (25) | 2.8% | 2011-2012 | cin |
| Matt Cassel (30) | 2.8% | 2005-2012 | 2TM | |
| Tony Romo (32) | 2.8% | 2004-2012 | dal | |
| Michael Vick (32) | 2.8% | 2001-2012 | 2TM | |
| 18. | Ben Roethlisberger (30) | 2.9% | 2004-2012 | pit |
| Alex Smith (28) | 2.9% | 2005-2012 | sfo | |
| Cam Newton (23) | 2.9% | 2011-2012 | car | |
| Matthew Stafford (24) | 2.9% | 2009-2012 | det | |
| Matt Hasselbeck (37) | 2.9% | 1999-2012 | 3TM | |
| 23. | David Carr (33) | 3.1% | 2002-2012 | 4TM |
| 24. | Carson Palmer (33) | 3.2% | 2004-2012 | 2TM |
| Eli Manning (31) | 3.2% | 2004-2012 | nyg | |
| Charlie Batch (38) | 3.2% | 1998-2012 | 2TM | |
| 27. | Tarvaris Jackson (29) | 3.3% | 2006-2012 | 3TM |
| 28. | Josh Freeman (24) | 3.4% | 2009-2012 | tam |
| Jay Cutler (29) | 3.4% | 2006-2012 | 2TM | |
| 30. | Chad Henne (27) | 3.5% | 2008-2012 | 2TM |
| 31. | Ryan Fitzpatrick (30) | 3.6% | 2005-2012 | 3TM |
| 32. | Mark Sanchez (26) | 3.7% | 2009-2012 | nyj |
| 33. | Derek Anderson (29) | 3.8% | 2006-2012 | 3TM |