| Rank | Player (age), + - HOFer, Bold - Active | Sk | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (40) | 503 | 1991-2009 | 4TM |
| 2. | Mark Brunell (39) | 389 | 1994-2009 | 4TM |
| 3. | Donovan McNabb (33) | 357 | 1999-2009 | phi |
| 4. | Kerry Collins (37) | 319 | 1995-2009 | 5TM |
| 5. | Daunte Culpepper (32) | 298 | 1999-2009 | 4TM |
| 6. | Matt Hasselbeck (34) | 280 | 1999-2009 | 2TM |
| 7. | David Carr (30) | 265 | 2002-2009 | 3TM |
| 8. | Kurt Warner (38) | 260 | 1998-2009 | 3TM |
| 9. | Marc Bulger (32) | 254 | 2002-2009 | ram |
| 10. | Ben Roethlisberger (27) | 242 | 2004-2009 | pit |
| 11. | Tom Brady (32) | 219 | 2000-2009 | nwe |
| 12. | Peyton Manning (33) | 215 | 1998-2009 | clt |
| 13. | Michael Vick (29) | 187 | 2001-2009 | 2TM |
| 14. | Jeff Garcia (39) | 181 | 1999-2009 | 5TM |
| 15. | Chad Pennington (33) | 162 | 2000-2009 | 2TM |
| 16. | Jake Delhomme (34) | 160 | 1999-2009 | 2TM |
| 17. | Drew Brees (30) | 159 | 2001-2009 | 2TM |
| 18. | Charlie Batch (35) | 152 | 1998-2009 | 2TM |
| 19. | Eli Manning (28) | 150 | 2004-2009 | nyg |
| 20. | David Garrard (31) | 146 | 2002-2009 | jax |
| 21. | Carson Palmer (30) | 134 | 2004-2009 | cin |
| 22. | Kyle Boller (28) | 119 | 2003-2009 | 2TM |
| 23. | Jason Campbell (28) | 109 | 2006-2009 | was |
| 24. | J.P. Losman (28) | 103 | 2004-2009 | 2TM |
| Alex Smith (25) | 103 | 2005-2009 | sfo | |
| 26. | Philip Rivers (28) | 102 | 2004-2009 | sdg |
| 27. | Tony Romo (29) | 99 | 2004-2009 | dal |
| 28. | Josh McCown (30) | 94 | 2002-2009 | 4TM |
| 29. | Matt Cassel (27) | 93 | 2005-2009 | 2TM |
| Aaron Rodgers (26) | 93 | 2005-2009 | gnb | |
| 31. | Kyle Orton (27) | 88 | 2005-2009 | 2TM |
| 32. | Byron Leftwich (29) | 87 | 2003-2009 | 4TM |
| 33. | Jay Cutler (26) | 86 | 2006-2009 | 2TM |
| 34. | Charlie Frye (28) | 79 | 2005-2009 | 3TM |
| 35. | Matt Schaub (28) | 76 | 2004-2009 | 2TM |
| 36. | JaMarcus Russell (24) | 70 | 2007-2009 | rai |
| 37. | Ryan Fitzpatrick (27) | 68 | 2005-2009 | 3TM |
| Joe Flacco (24) | 68 | 2008-2009 | rav | |
| 39. | Todd Collins (38) | 65 | 1995-2009 | 3TM |
| 40. | Vince Young (26) | 62 | 2006-2009 | oti |
| 41. | Trent Edwards (26) | 58 | 2007-2009 | buf |
| Rex Grossman (29) | 58 | 2003-2009 | 2TM | |
| 43. | Chris Simms (29) | 49 | 2004-2009 | 3TM |
| Billy Volek (33) | 49 | 2001-2009 | 2TM | |
| 45. | Shaun Hill (29) | 47 | 2005-2009 | 2TM |
| Derek Anderson (26) | 47 | 2006-2009 | cle | |
| 47. | Seneca Wallace (29) | 43 | 2005-2009 | sea |
| 48. | Bruce Gradkowski (26) | 42 | 2006-2009 | 3TM |
| 49. | Tarvaris Jackson (26) | 41 | 2006-2009 | min |
| 50. | J.T. O'Sullivan (30) | 38 | 2004-2009 | 4TM |