| Rank | Player (age), + - HOFer, Bold - Active | Yds | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (40) | 3,251 | 1991-2009 | 4TM |
| 2. | Mark Brunell (39) | 2,388 | 1994-2009 | 4TM |
| 3. | Donovan McNabb (33) | 2,156 | 1999-2009 | phi |
| 4. | Kerry Collins (37) | 2,099 | 1995-2009 | 5TM |
| 5. | Marc Bulger (32) | 1,863 | 2002-2009 | ram |
| 6. | Daunte Culpepper (32) | 1,659 | 1999-2009 | 4TM |
| 7. | Kurt Warner (38) | 1,625 | 1998-2009 | 3TM |
| 8. | Matt Hasselbeck (34) | 1,618 | 1999-2009 | 2TM |
| 9. | David Carr (30) | 1,553 | 2002-2009 | 3TM |
| 10. | Ben Roethlisberger (27) | 1,462 | 2004-2009 | pit |
| 11. | Peyton Manning (33) | 1,376 | 1998-2009 | clt |
| 12. | Tom Brady (32) | 1,356 | 2000-2009 | nwe |
| 13. | Jake Delhomme (34) | 1,174 | 1999-2009 | 2TM |
| 14. | Michael Vick (29) | 1,153 | 2001-2009 | 2TM |
| 15. | Drew Brees (30) | 1,114 | 2001-2009 | 2TM |
| 16. | Chad Pennington (33) | 965 | 2000-2009 | 2TM |
| 17. | Jeff Garcia (39) | 947 | 1999-2009 | 5TM |
| 18. | Eli Manning (28) | 942 | 2004-2009 | nyg |
| 19. | Charlie Batch (35) | 847 | 1998-2009 | 2TM |
| 20. | Carson Palmer (30) | 841 | 2004-2009 | cin |
| 21. | David Garrard (31) | 747 | 2002-2009 | jax |
| 22. | Kyle Boller (28) | 705 | 2003-2009 | 2TM |
| 23. | Josh McCown (30) | 686 | 2002-2009 | 4TM |
| 24. | Philip Rivers (28) | 612 | 2004-2009 | sdg |
| 25. | Jason Campbell (28) | 603 | 2006-2009 | was |
| 26. | Alex Smith (25) | 584 | 2005-2009 | sfo |
| 27. | Aaron Rodgers (26) | 555 | 2005-2009 | gnb |
| 28. | Tony Romo (29) | 551 | 2004-2009 | dal |
| 29. | Matt Schaub (28) | 442 | 2004-2009 | 2TM |
| Kyle Orton (27) | 442 | 2005-2009 | 2TM | |
| 31. | Jay Cutler (26) | 434 | 2006-2009 | 2TM |
| 32. | Todd Collins (38) | 432 | 1995-2009 | 3TM |
| 33. | Matt Cassel (27) | 430 | 2005-2009 | 2TM |
| 34. | Byron Leftwich (29) | 421 | 2003-2009 | 4TM |
| 35. | Joe Flacco (24) | 396 | 2008-2009 | rav |
| 36. | JaMarcus Russell (24) | 392 | 2007-2009 | rai |
| 37. | Trent Edwards (26) | 368 | 2007-2009 | buf |
| 38. | Chris Simms (29) | 361 | 2004-2009 | 3TM |
| 39. | Derek Anderson (26) | 334 | 2006-2009 | cle |
| 40. | Billy Volek (33) | 319 | 2001-2009 | 2TM |
| 41. | Vince Young (26) | 308 | 2006-2009 | oti |
| 42. | Shaun Hill (29) | 286 | 2005-2009 | 2TM |
| 43. | Ryan Fitzpatrick (27) | 268 | 2005-2009 | 3TM |
| 44. | Seneca Wallace (29) | 251 | 2005-2009 | sea |
| 45. | Luke McCown (28) | 233 | 2004-2009 | 3TM |
| 46. | J.T. O'Sullivan (30) | 215 | 2004-2009 | 4TM |
| 47. | Matt Leinart (26) | 209 | 2006-2009 | crd |
| 48. | Tarvaris Jackson (26) | 204 | 2006-2009 | min |
| 49. | Bruce Gradkowski (26) | 196 | 2006-2009 | 3TM |
| 50. | Tyler Thigpen (25) | 171 | 2007-2009 | 2TM |