| Rank | Player (age), + - HOFer, Bold - Active | TD | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (40) | 485 | 1991-2009 | 4TM |
| 2. | Peyton Manning (33) | 354 | 1998-2009 | clt |
| 3. | Tom Brady (32) | 217 | 2000-2009 | nwe |
| 4. | Donovan McNabb (33) | 208 | 1999-2009 | phi |
| 5. | Kurt Warner (38) | 202 | 1998-2009 | 3TM |
| 6. | Kerry Collins (37) | 191 | 1995-2009 | 5TM |
| 7. | Drew Brees (30) | 190 | 2001-2009 | 2TM |
| 8. | Mark Brunell (39) | 182 | 1994-2009 | 4TM |
| 9. | Jeff Garcia (39) | 161 | 1999-2009 | 5TM |
| 10. | Matt Hasselbeck (34) | 158 | 1999-2009 | 2TM |
| 11. | Daunte Culpepper (32) | 147 | 1999-2009 | 4TM |
| 12. | Jake Delhomme (34) | 123 | 1999-2009 | 2TM |
| 13. | Marc Bulger (32) | 122 | 2002-2009 | ram |
| 14. | Carson Palmer (30) | 121 | 2004-2009 | cin |
| 15. | Ben Roethlisberger (27) | 118 | 2004-2009 | pit |
| 16. | Eli Manning (28) | 116 | 2004-2009 | nyg |
| 17. | Chad Pennington (33) | 102 | 2000-2009 | 2TM |
| 18. | Tony Romo (29) | 96 | 2004-2009 | dal |
| 19. | Philip Rivers (28) | 95 | 2004-2009 | sdg |
| 20. | Michael Vick (29) | 71 | 2001-2009 | 2TM |
| 21. | Jay Cutler (26) | 69 | 2006-2009 | 2TM |
| 22. | David Carr (30) | 65 | 2002-2009 | 3TM |
| 23. | David Garrard (31) | 59 | 2002-2009 | jax |
| 24. | Byron Leftwich (29) | 58 | 2003-2009 | 4TM |
| 25. | Charlie Batch (35) | 57 | 1998-2009 | 2TM |
| 26. | Matt Schaub (28) | 49 | 2004-2009 | 2TM |
| 27. | Aaron Rodgers (26) | 48 | 2005-2009 | gnb |
| 28. | Kyle Boller (28) | 47 | 2003-2009 | 2TM |
| 29. | Derek Anderson (26) | 45 | 2006-2009 | cle |
| Jason Campbell (28) | 45 | 2006-2009 | was | |
| 31. | Kyle Orton (27) | 41 | 2005-2009 | 2TM |
| 32. | Josh McCown (30) | 35 | 2002-2009 | 4TM |
| Matt Cassel (27) | 35 | 2005-2009 | 2TM | |
| 34. | Matt Ryan (24) | 32 | 2008-2009 | atl |
| 35. | Alex Smith (25) | 28 | 2005-2009 | sfo |
| 36. | Joe Flacco (24) | 26 | 2008-2009 | rav |
| Billy Volek (33) | 26 | 2001-2009 | 2TM | |
| 38. | Vince Young (26) | 25 | 2006-2009 | oti |
| Seneca Wallace (29) | 25 | 2005-2009 | sea | |
| 40. | Trent Edwards (26) | 24 | 2007-2009 | buf |
| 41. | Shaun Hill (29) | 23 | 2005-2009 | 2TM |
| 42. | Todd Collins (38) | 22 | 1995-2009 | 3TM |
| 43. | Tarvaris Jackson (26) | 21 | 2006-2009 | min |
| 44. | Tyler Thigpen (25) | 18 | 2007-2009 | 2TM |
| 45. | JaMarcus Russell (24) | 17 | 2007-2009 | rai |
| Chris Redman (32) | 17 | 2000-2009 | 2TM | |
| 47. | Ryan Fitzpatrick (27) | 15 | 2005-2009 | 3TM |
| 48. | Matt Leinart (26) | 14 | 2006-2009 | crd |
| 49. | Chris Simms (29) | 12 | 2004-2009 | 3TM |
| 50. | Bruce Gradkowski (26) | 11 | 2006-2009 | 3TM |
| Matthew Stafford (21) | 11 | 2009 | det |