| Rank | Player (age), + - HOFer, Bold - Active | Yds | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (40) | 67,396 | 1991-2009 | 4TM |
| 2. | Peyton Manning (33) | 48,500 | 1998-2009 | clt |
| 3. | Kerry Collins (37) | 38,464 | 1995-2009 | 5TM |
| 4. | Mark Brunell (39) | 31,826 | 1994-2009 | 4TM |
| 5. | Kurt Warner (38) | 31,106 | 1998-2009 | 3TM |
| 6. | Donovan McNabb (33) | 31,005 | 1999-2009 | phi |
| 7. | Tom Brady (32) | 29,185 | 2000-2009 | nwe |
| 8. | Drew Brees (30) | 28,817 | 2001-2009 | 2TM |
| 9. | Jeff Garcia (39) | 25,537 | 1999-2009 | 5TM |
| 10. | Matt Hasselbeck (34) | 25,171 | 1999-2009 | 2TM |
| 11. | Daunte Culpepper (32) | 23,592 | 1999-2009 | 4TM |
| 12. | Marc Bulger (32) | 22,599 | 2002-2009 | ram |
| 13. | Jake Delhomme (34) | 19,762 | 1999-2009 | 2TM |
| 14. | Chad Pennington (33) | 17,804 | 2000-2009 | 2TM |
| 15. | Carson Palmer (30) | 17,640 | 2004-2009 | cin |
| 16. | Ben Roethlisberger (27) | 17,443 | 2004-2009 | pit |
| 17. | Eli Manning (28) | 16,693 | 2004-2009 | nyg |
| 18. | David Carr (30) | 14,313 | 2002-2009 | 3TM |
| 19. | Philip Rivers (28) | 13,173 | 2004-2009 | sdg |
| 20. | Tony Romo (29) | 13,028 | 2004-2009 | dal |
| 21. | David Garrard (31) | 11,760 | 2002-2009 | jax |
| 22. | Michael Vick (29) | 11,511 | 2001-2009 | 2TM |
| 23. | Jay Cutler (26) | 11,377 | 2006-2009 | 2TM |
| 24. | Byron Leftwich (29) | 10,218 | 2003-2009 | 4TM |
| 25. | Jason Campbell (28) | 9,112 | 2006-2009 | was |
| 26. | Matt Schaub (28) | 8,970 | 2004-2009 | 2TM |
| 27. | Kyle Boller (28) | 8,327 | 2003-2009 | 2TM |
| 28. | Kyle Orton (27) | 7,350 | 2005-2009 | 2TM |
| 29. | Derek Anderson (26) | 6,876 | 2006-2009 | cle |
| 30. | Aaron Rodgers (26) | 6,811 | 2005-2009 | gnb |
| 31. | Josh McCown (30) | 6,584 | 2002-2009 | 4TM |
| 32. | Trent Edwards (26) | 5,499 | 2007-2009 | buf |
| 33. | Alex Smith (25) | 5,487 | 2005-2009 | sfo |
| 34. | Vince Young (26) | 5,471 | 2006-2009 | oti |
| 35. | Matt Ryan (24) | 5,448 | 2008-2009 | atl |
| 36. | Matt Cassel (27) | 5,418 | 2005-2009 | 2TM |
| 37. | Joe Flacco (24) | 5,170 | 2008-2009 | rav |
| 38. | Todd Collins (38) | 4,422 | 1995-2009 | 3TM |
| 39. | JaMarcus Russell (24) | 3,860 | 2007-2009 | rai |
| 40. | Tarvaris Jackson (26) | 3,524 | 2006-2009 | min |
| 41. | Seneca Wallace (29) | 3,523 | 2005-2009 | sea |
| 42. | Billy Volek (33) | 3,515 | 2001-2009 | 2TM |
| 43. | Matt Leinart (26) | 3,503 | 2006-2009 | crd |
| 44. | Shaun Hill (29) | 3,490 | 2005-2009 | 2TM |
| 45. | Chris Simms (29) | 3,107 | 2004-2009 | 3TM |
| 46. | Ryan Fitzpatrick (27) | 3,044 | 2005-2009 | 3TM |
| 47. | Tyler Thigpen (25) | 2,649 | 2007-2009 | 2TM |
| 48. | Chris Redman (32) | 2,190 | 2000-2009 | 2TM |
| 49. | Bruce Gradkowski (26) | 1,980 | 2006-2009 | 3TM |
| 50. | J.T. O'Sullivan (30) | 1,826 | 2004-2009 | 4TM |