| Rank | Player (age), + - HOFer, Bold - Active | Yds | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (40) | 69,329 | 1991-2009 | 4TM |
| 2. | Peyton Manning (33) | 50,128 | 1998-2009 | clt |
| 3. | Kerry Collins (37) | 38,618 | 1995-2009 | 5TM |
| 4. | Donovan McNabb (33) | 32,873 | 1999-2009 | phi |
| 5. | Kurt Warner (38) | 32,344 | 1998-2009 | 3TM |
| 6. | Mark Brunell (39) | 31,928 | 1994-2009 | 4TM |
| 7. | Tom Brady (32) | 30,844 | 2000-2009 | nwe |
| 8. | Drew Brees (30) | 30,646 | 2001-2009 | 2TM |
| 9. | Matt Hasselbeck (34) | 26,578 | 1999-2009 | 2TM |
| 10. | Jeff Garcia (39) | 25,537 | 1999-2009 | 5TM |
| 11. | Daunte Culpepper (32) | 24,153 | 1999-2009 | 4TM |
| 12. | Marc Bulger (32) | 22,814 | 2002-2009 | ram |
| 13. | Jake Delhomme (34) | 19,892 | 1999-2009 | 2TM |
| 14. | Ben Roethlisberger (27) | 19,302 | 2004-2009 | pit |
| 15. | Carson Palmer (30) | 18,724 | 2004-2009 | cin |
| 16. | Eli Manning (28) | 18,644 | 2004-2009 | nyg |
| 17. | Chad Pennington (33) | 17,804 | 2000-2009 | 2TM |
| 18. | Tony Romo (29) | 15,045 | 2004-2009 | dal |
| 19. | Philip Rivers (28) | 14,951 | 2004-2009 | sdg |
| 20. | David Carr (30) | 14,366 | 2002-2009 | 3TM |
| 21. | David Garrard (31) | 13,269 | 2002-2009 | jax |
| 22. | Jay Cutler (26) | 12,690 | 2006-2009 | 2TM |
| 23. | Michael Vick (29) | 11,591 | 2001-2009 | 2TM |
| 24. | Matt Schaub (28) | 11,087 | 2004-2009 | 2TM |
| 25. | Jason Campbell (28) | 10,860 | 2006-2009 | was |
| 26. | Byron Leftwich (29) | 10,218 | 2003-2009 | 4TM |
| 27. | Charlie Batch (35) | 10,050 | 1998-2009 | 2TM |
| 28. | Kyle Orton (27) | 9,121 | 2005-2009 | 2TM |
| 29. | Aaron Rodgers (26) | 8,801 | 2005-2009 | gnb |
| 30. | Kyle Boller (28) | 8,745 | 2003-2009 | 2TM |
| 31. | Derek Anderson (26) | 7,083 | 2006-2009 | cle |
| 32. | Alex Smith (25) | 7,029 | 2005-2009 | sfo |
| 33. | Matt Cassel (27) | 6,870 | 2005-2009 | 2TM |
| 34. | Vince Young (26) | 6,843 | 2006-2009 | oti |
| 35. | Josh McCown (30) | 6,584 | 2002-2009 | 4TM |
| Joe Flacco (24) | 6,584 | 2008-2009 | rav | |
| 37. | Matt Ryan (24) | 6,356 | 2008-2009 | atl |
| 38. | J.P. Losman (28) | 6,211 | 2004-2009 | 2TM |
| 39. | Rex Grossman (29) | 6,197 | 2003-2009 | 2TM |
| 40. | Trent Edwards (26) | 5,498 | 2007-2009 | buf |
| 41. | Todd Collins (38) | 4,479 | 1995-2009 | 3TM |
| 42. | Charlie Frye (28) | 4,154 | 2005-2009 | 3TM |
| 43. | Ryan Fitzpatrick (27) | 4,104 | 2005-2009 | 3TM |
| 44. | JaMarcus Russell (24) | 4,083 | 2007-2009 | rai |
| 45. | Matt Leinart (26) | 3,893 | 2006-2009 | crd |
| 46. | Billy Volek (33) | 3,746 | 2001-2009 | 2TM |
| 47. | Tarvaris Jackson (26) | 3,643 | 2006-2009 | min |
| 48. | Seneca Wallace (29) | 3,547 | 2005-2009 | sea |
| 49. | Shaun Hill (29) | 3,490 | 2005-2009 | 2TM |
| 50. | Chris Simms (29) | 3,117 | 2004-2009 | 3TM |