| Rank | Player (age), + - HOFer, Bold - Active | Att | Years | Teams |
|---|---|---|---|---|
| 1. | Edgerrin James (31) | 3,028 | 1999-2009 | 3TM |
| 2. | LaDainian Tomlinson (30) | 2,772 | 2001-2009 | sdg |
| 3. | Jamal Lewis (30) | 2,507 | 2000-2009 | 2TM |
| 4. | Fred Taylor (33) | 2,473 | 1998-2009 | 2TM |
| 5. | Clinton Portis (28) | 2,176 | 2002-2009 | 2TM |
| 6. | Thomas Jones (31) | 2,119 | 2000-2009 | 4TM |
| 7. | Ricky Williams (32) | 2,050 | 1999-2009 | 2TM |
| 8. | Ahman Green (32) | 2,026 | 1998-2009 | 3TM |
| 9. | Steven Jackson (26) | 1,415 | 2004-2009 | ram |
| 10. | Willis McGahee (28) | 1,392 | 2004-2009 | 2TM |
| 11. | Larry Johnson (30) | 1,375 | 2003-2009 | 2TM |
| 12. | Brian Westbrook (30) | 1,294 | 2002-2009 | phi |
| 13. | Willie Parker (29) | 1,216 | 2004-2009 | pit |
| 14. | Julius Jones (28) | 1,150 | 2004-2009 | 2TM |
| 15. | Frank Gore (26) | 1,044 | 2005-2009 | sfo |
| 16. | Chester Taylor (30) | 986 | 2002-2009 | 2TM |
| 17. | Ronnie Brown (28) | 928 | 2005-2009 | mia |
| 18. | LaMont Jordan (31) | 892 | 2001-2009 | 4TM |
| 19. | Cedric Benson (27) | 839 | 2005-2009 | 2TM |
| 20. | Michael Bennett (31) | 829 | 2001-2009 | 4TM |
| 21. | Marion Barber (26) | 818 | 2005-2009 | dal |
| 22. | Kevin Faulk (33) | 814 | 1999-2009 | nwe |
| 23. | Adrian Peterson (24) | 782 | 2007-2009 | min |
| 24. | Justin Fargas (29) | 780 | 2003-2009 | rai |
| 25. | Ladell Betts (30) | 772 | 2002-2009 | was |
| 26. | Michael Turner (27) | 769 | 2004-2009 | 2TM |
| 27. | Joseph Addai (26) | 768 | 2006-2009 | clt |
| 28. | Cadillac Williams (27) | 738 | 2005-2009 | tam |
| 29. | DeAngelo Williams (26) | 719 | 2006-2009 | car |
| 30. | Brandon Jacobs (27) | 706 | 2005-2009 | nyg |
| 31. | Maurice Jones-Drew (24) | 699 | 2006-2009 | jax |
| 32. | Chris Brown (28) | 686 | 2003-2009 | 2TM |
| 33. | Ryan Grant (27) | 668 | 2007-2009 | gnb |
| 34. | Sammy Morris (32) | 645 | 2000-2009 | 3TM |
| 35. | Maurice Morris (30) | 640 | 2002-2009 | 2TM |
| 36. | LenDale White (25) | 623 | 2006-2009 | oti |
| 37. | Marshawn Lynch (23) | 609 | 2007-2009 | buf |
| 38. | Brett Favre (40) | 582 | 1991-2009 | 4TM |
| 39. | Donovan McNabb (33) | 552 | 1999-2009 | phi |
| 40. | Correll Buckhalter (31) | 542 | 2001-2009 | 2TM |
| 41. | Michael Vick (29) | 541 | 2001-2009 | 2TM |
| 42. | Mark Brunell (39) | 510 | 1994-2009 | 4TM |
| 43. | Daunte Culpepper (32) | 499 | 1999-2009 | 4TM |
| 44. | Laurence Maroney (24) | 482 | 2006-2009 | nwe |
| 45. | Reggie Bush (24) | 473 | 2006-2009 | nor |
| 46. | Jeff Garcia (39) | 468 | 1999-2009 | 5TM |
| 47. | Matt Forte (24) | 459 | 2008-2009 | chi |
| 48. | Mewelde Moore (27) | 431 | 2004-2009 | 2TM |
| 49. | Chris Johnson (24) | 421 | 2008-2009 | oti |
| 50. | Tony Richardson (38) | 420 | 1995-2009 | 3TM |