| Rank | Player (age), + - HOFer, Bold - Active | TD | Years | Teams |
|---|---|---|---|---|
| 1. | LaDainian Tomlinson (30) | 132 | 2001-2009 | sdg |
| 2. | Edgerrin James (31) | 80 | 1999-2009 | 3TM |
| 3. | Clinton Portis (28) | 73 | 2002-2009 | 2TM |
| 4. | Fred Taylor (33) | 64 | 1998-2009 | 2TM |
| 5. | Ricky Williams (32) | 59 | 1999-2009 | 2TM |
| Ahman Green (32) | 59 | 1998-2009 | 3TM | |
| 7. | Jamal Lewis (30) | 58 | 2000-2009 | 2TM |
| 8. | Thomas Jones (31) | 56 | 2000-2009 | 4TM |
| 9. | Larry Johnson (30) | 55 | 2003-2009 | 2TM |
| 10. | Maurice Jones-Drew (24) | 47 | 2006-2009 | jax |
| 11. | Willis McGahee (28) | 43 | 2004-2009 | 2TM |
| 12. | Steven Jackson (26) | 40 | 2004-2009 | ram |
| Marion Barber (26) | 40 | 2005-2009 | dal | |
| 14. | Brandon Jacobs (27) | 38 | 2005-2009 | nyg |
| 15. | Brian Westbrook (30) | 37 | 2002-2009 | phi |
| 16. | Daunte Culpepper (32) | 34 | 1999-2009 | 4TM |
| 17. | Michael Turner (27) | 33 | 2004-2009 | 2TM |
| Adrian Peterson (24) | 33 | 2007-2009 | min | |
| 19. | Ronnie Brown (28) | 31 | 2005-2009 | mia |
| Joseph Addai (26) | 31 | 2006-2009 | clt | |
| 21. | DeAngelo Williams (26) | 30 | 2006-2009 | car |
| 22. | LaMont Jordan (31) | 28 | 2001-2009 | 4TM |
| Frank Gore (26) | 28 | 2005-2009 | sfo | |
| 24. | Donovan McNabb (33) | 27 | 1999-2009 | phi |
| 25. | Jeff Garcia (39) | 26 | 1999-2009 | 5TM |
| 26. | Sammy Morris (32) | 25 | 2000-2009 | 3TM |
| 27. | Willie Parker (29) | 24 | 2004-2009 | pit |
| 28. | LenDale White (25) | 23 | 2006-2009 | oti |
| 29. | Chester Taylor (30) | 22 | 2002-2009 | 2TM |
| Julius Jones (28) | 22 | 2004-2009 | 2TM | |
| 31. | Michael Vick (29) | 21 | 2001-2009 | 2TM |
| 32. | Correll Buckhalter (31) | 19 | 2001-2009 | 2TM |
| 33. | Cedric Benson (27) | 18 | 2005-2009 | 2TM |
| Laurence Maroney (24) | 18 | 2006-2009 | nwe | |
| 35. | Chris Brown (28) | 17 | 2003-2009 | 2TM |
| Reggie Bush (24) | 17 | 2006-2009 | nor | |
| Ryan Grant (27) | 17 | 2007-2009 | gnb | |
| Chris Johnson (24) | 17 | 2008-2009 | oti | |
| Peyton Manning (33) | 17 | 1998-2009 | clt | |
| Cadillac Williams (27) | 17 | 2005-2009 | tam | |
| 41. | Jonathan Stewart (22) | 16 | 2008-2009 | car |
| Marshawn Lynch (23) | 16 | 2007-2009 | buf | |
| 43. | Pierre Thomas (25) | 15 | 2007-2009 | nor |
| Tony Richardson (38) | 15 | 1995-2009 | 3TM | |
| Tim Hightower (23) | 15 | 2008-2009 | crd | |
| Mark Brunell (39) | 15 | 1994-2009 | 4TM | |
| 47. | Kevin Faulk (33) | 14 | 1999-2009 | nwe |
| Brett Favre (40) | 14 | 1991-2009 | 4TM | |
| Earnest Graham (29) | 14 | 2004-2009 | tam | |
| 50. | Leon Washington (27) | 13 | 2006-2009 | nyj |
| Ladell Betts (30) | 13 | 2002-2009 | was | |
| Michael Bennett (31) | 13 | 2001-2009 | 4TM | |
| Mike Bell (26) | 13 | 2006-2009 | 2TM |