| Rank | Player (age), + - HOFer, Bold - Active | Yds | Years | Teams |
|---|---|---|---|---|
| 1. | Edgerrin James (31) | 12,246 | 1999-2009 | 3TM |
| 2. | LaDainian Tomlinson (30) | 12,145 | 2001-2009 | sdg |
| 3. | Fred Taylor (33) | 11,472 | 1998-2009 | 2TM |
| 4. | Jamal Lewis (30) | 10,492 | 2000-2009 | 2TM |
| 5. | Clinton Portis (28) | 9,696 | 2002-2009 | 2TM |
| 6. | Ahman Green (32) | 9,100 | 1998-2009 | 3TM |
| 7. | Thomas Jones (31) | 8,596 | 2000-2009 | 4TM |
| 8. | Ricky Williams (32) | 8,448 | 1999-2009 | 2TM |
| 9. | Steven Jackson (26) | 6,206 | 2004-2009 | ram |
| 10. | Larry Johnson (30) | 5,996 | 2003-2009 | 2TM |
| 11. | Brian Westbrook (30) | 5,946 | 2002-2009 | phi |
| 12. | Willis McGahee (28) | 5,479 | 2004-2009 | 2TM |
| 13. | Willie Parker (29) | 5,183 | 2004-2009 | pit |
| 14. | Frank Gore (26) | 4,992 | 2005-2009 | sfo |
| 15. | Julius Jones (28) | 4,574 | 2004-2009 | 2TM |
| 16. | Chester Taylor (30) | 4,197 | 2002-2009 | 2TM |
| 17. | Ronnie Brown (28) | 4,081 | 2005-2009 | mia |
| 18. | Adrian Peterson (24) | 4,018 | 2007-2009 | min |
| 19. | Michael Vick (29) | 3,886 | 2001-2009 | 2TM |
| 20. | Michael Turner (27) | 3,787 | 2004-2009 | 2TM |
| 21. | DeAngelo Williams (26) | 3,715 | 2006-2009 | car |
| 22. | LaMont Jordan (31) | 3,707 | 2001-2009 | 4TM |
| 23. | Michael Bennett (31) | 3,664 | 2001-2009 | 4TM |
| 24. | Marion Barber (26) | 3,525 | 2005-2009 | dal |
| 25. | Maurice Jones-Drew (24) | 3,393 | 2006-2009 | jax |
| 26. | Kevin Faulk (33) | 3,358 | 1999-2009 | nwe |
| 27. | Brandon Jacobs (27) | 3,237 | 2005-2009 | nyg |
| 28. | Cedric Benson (27) | 3,199 | 2005-2009 | 2TM |
| 29. | Justin Fargas (29) | 3,182 | 2003-2009 | rai |
| Donovan McNabb (33) | 3,182 | 1999-2009 | phi | |
| 31. | Ladell Betts (30) | 3,171 | 2002-2009 | was |
| 32. | Joseph Addai (26) | 3,137 | 2006-2009 | clt |
| 33. | Chris Brown (28) | 2,899 | 2003-2009 | 2TM |
| 34. | Ryan Grant (27) | 2,859 | 2007-2009 | gnb |
| 35. | Cadillac Williams (27) | 2,835 | 2005-2009 | tam |
| 36. | Maurice Morris (30) | 2,748 | 2002-2009 | 2TM |
| 37. | Sammy Morris (32) | 2,689 | 2000-2009 | 3TM |
| 38. | Daunte Culpepper (32) | 2,605 | 1999-2009 | 4TM |
| 39. | Correll Buckhalter (31) | 2,519 | 2001-2009 | 2TM |
| 40. | Mark Brunell (39) | 2,424 | 1994-2009 | 4TM |
| 41. | Marshawn Lynch (23) | 2,405 | 2007-2009 | buf |
| 42. | LenDale White (25) | 2,331 | 2006-2009 | oti |
| 43. | Chris Johnson (24) | 2,319 | 2008-2009 | oti |
| 44. | Jeff Garcia (39) | 2,140 | 1999-2009 | 5TM |
| 45. | Laurence Maroney (24) | 2,051 | 2006-2009 | nwe |
| 46. | Mewelde Moore (27) | 1,983 | 2004-2009 | 2TM |
| 47. | Derrick Ward (29) | 1,967 | 2004-2009 | 2TM |
| 48. | Reggie Bush (24) | 1,827 | 2006-2009 | nor |
| 49. | Brett Favre (40) | 1,826 | 1991-2009 | 4TM |
| 50. | Jerious Norwood (26) | 1,813 | 2006-2009 | atl |