| Rank | Player (age), + - HOFer, Bold - Active | Yds | Years | Teams |
|---|---|---|---|---|
| 1. | LaDainian Tomlinson (30) | 12,490 | 2001-2009 | sdg |
| 2. | Edgerrin James (31) | 12,246 | 1999-2009 | 3TM |
| 3. | Fred Taylor (33) | 11,540 | 1998-2009 | 2TM |
| 4. | Jamal Lewis (30) | 10,607 | 2000-2009 | 2TM |
| 5. | Clinton Portis (28) | 9,696 | 2002-2009 | 2TM |
| 6. | Thomas Jones (31) | 9,217 | 2000-2009 | 4TM |
| 7. | Ahman Green (32) | 9,205 | 1998-2009 | 3TM |
| 8. | Ricky Williams (32) | 8,892 | 1999-2009 | 2TM |
| 9. | Steven Jackson (26) | 6,707 | 2004-2009 | ram |
| 10. | Larry Johnson (30) | 6,200 | 2003-2009 | 2TM |
| 11. | Brian Westbrook (30) | 5,995 | 2002-2009 | phi |
| 12. | Willis McGahee (28) | 5,787 | 2004-2009 | 2TM |
| 13. | Frank Gore (26) | 5,561 | 2005-2009 | sfo |
| 14. | Willie Parker (29) | 5,378 | 2004-2009 | pit |
| 15. | Julius Jones (28) | 4,845 | 2004-2009 | 2TM |
| 16. | Adrian Peterson (24) | 4,484 | 2007-2009 | min |
| 17. | Chester Taylor (30) | 4,396 | 2002-2009 | 2TM |
| 18. | Ronnie Brown (28) | 4,081 | 2005-2009 | mia |
| 19. | Marion Barber (26) | 3,984 | 2005-2009 | dal |
| 20. | Michael Vick (29) | 3,954 | 2001-2009 | 2TM |
| 21. | Maurice Jones-Drew (24) | 3,924 | 2006-2009 | jax |
| 22. | DeAngelo Williams (26) | 3,850 | 2006-2009 | car |
| 23. | Michael Turner (27) | 3,827 | 2004-2009 | 2TM |
| 24. | LaMont Jordan (31) | 3,734 | 2001-2009 | 4TM |
| 25. | Michael Bennett (31) | 3,692 | 2001-2009 | 4TM |
| 26. | Cedric Benson (27) | 3,591 | 2005-2009 | 2TM |
| 27. | Joseph Addai (26) | 3,525 | 2006-2009 | clt |
| 28. | Kevin Faulk (33) | 3,505 | 1999-2009 | nwe |
| 29. | Brandon Jacobs (27) | 3,455 | 2005-2009 | nyg |
| 30. | Ryan Grant (27) | 3,412 | 2007-2009 | gnb |
| 31. | Justin Fargas (29) | 3,369 | 2003-2009 | rai |
| 32. | Donovan McNabb (33) | 3,249 | 1999-2009 | phi |
| 33. | Cadillac Williams (27) | 3,240 | 2005-2009 | tam |
| 34. | Chris Johnson (24) | 3,234 | 2008-2009 | oti |
| 35. | Ladell Betts (30) | 3,176 | 2002-2009 | was |
| 36. | Chris Brown (28) | 3,024 | 2003-2009 | 2TM |
| 37. | Maurice Morris (30) | 2,996 | 2002-2009 | 2TM |
| 38. | Sammy Morris (32) | 2,899 | 2000-2009 | 3TM |
| 39. | Correll Buckhalter (31) | 2,797 | 2001-2009 | 2TM |
| 40. | Daunte Culpepper (32) | 2,652 | 1999-2009 | 4TM |
| 41. | Marshawn Lynch (23) | 2,601 | 2007-2009 | buf |
| 42. | Laurence Maroney (24) | 2,430 | 2006-2009 | nwe |
| 43. | Mark Brunell (39) | 2,421 | 1994-2009 | 4TM |
| 44. | LenDale White (25) | 2,349 | 2006-2009 | oti |
| 45. | Matt Forte (24) | 2,167 | 2008-2009 | chi |
| 46. | Derrick Ward (29) | 2,159 | 2004-2009 | 2TM |
| 47. | Jeff Garcia (39) | 2,140 | 1999-2009 | 5TM |
| 48. | Mewelde Moore (27) | 1,991 | 2004-2009 | 2TM |
| 49. | Jerious Norwood (26) | 1,987 | 2006-2009 | atl |
| 50. | Jonathan Stewart (22) | 1,969 | 2008-2009 | car |