| Rank | Player (age), + - HOFer, Bold - Active | Y/A | Years | Teams |
|---|---|---|---|---|
| 1. | Donovan McNabb (32) | 5.9 | 1999-2008 | phi |
| 2. | Adrian Peterson (23) | 5.3 | 2007-2008 | min |
| 3. | Daunte Culpepper (31) | 5.2 | 1999-2008 | 4TM |
| 4. | Maurice Jones-Drew (23) | 4.9 | 2006-2008 | jax |
| Michael Turner (26) | 4.9 | 2004-2008 | 2TM | |
| 6. | Frank Gore (25) | 4.8 | 2005-2008 | sfo |
| Brandon Jacobs (26) | 4.8 | 2005-2008 | nyg | |
| Tatum Bell (27) | 4.8 | 2004-2008 | 2TM | |
| DeAngelo Williams (25) | 4.8 | 2006-2008 | car | |
| 10. | Brian Westbrook (29) | 4.7 | 2002-2008 | phi |
| 11. | Fred Taylor (32) | 4.6 | 1998-2008 | jax |
| Jeff Garcia (38) | 4.6 | 1999-2008 | 5TM | |
| Clinton Portis (27) | 4.6 | 2002-2008 | 2TM | |
| 14. | Larry Johnson (29) | 4.5 | 2003-2008 | kan |
| Ahman Green (31) | 4.5 | 1998-2008 | 3TM | |
| LaDainian Tomlinson (29) | 4.5 | 2001-2008 | sdg | |
| 17. | Michael Bennett (30) | 4.4 | 2001-2008 | 4TM |
| Correll Buckhalter (30) | 4.4 | 2001-2008 | phi | |
| Willie Parker (28) | 4.4 | 2004-2008 | pit | |
| Ronnie Brown (27) | 4.4 | 2005-2008 | mia | |
| Marion Barber (25) | 4.4 | 2005-2008 | dal | |
| 22. | Steven Jackson (25) | 4.3 | 2004-2008 | ram |
| Chester Taylor (29) | 4.3 | 2002-2008 | 2TM | |
| Maurice Morris (29) | 4.3 | 2002-2008 | sea | |
| Shaun Alexander (31) | 4.3 | 2000-2008 | 2TM | |
| Deuce McAllister (30) | 4.3 | 2001-2008 | nor | |
| 27. | Jamal Lewis (29) | 4.2 | 2000-2008 | 2TM |
| Joseph Addai (25) | 4.2 | 2006-2008 | clt | |
| Ladell Betts (29) | 4.2 | 2002-2008 | was | |
| LaMont Jordan (30) | 4.2 | 2001-2008 | 3TM | |
| 31. | Earnest Graham (28) | 4.1 | 2004-2008 | tam |
| Warrick Dunn (33) | 4.1 | 1997-2008 | 2TM | |
| Justin Fargas (28) | 4.1 | 2003-2008 | rai | |
| Sammy Morris (31) | 4.1 | 2000-2008 | 3TM | |
| Dominic Rhodes (29) | 4.1 | 2001-2008 | 2TM | |
| Edgerrin James (30) | 4.1 | 1999-2008 | 2TM | |
| 37. | Ricky Williams (31) | 4.0 | 1999-2008 | 2TM |
| Michael Pittman (33) | 4.0 | 1998-2008 | 3TM | |
| Julius Jones (27) | 4.0 | 2004-2008 | 2TM | |
| Kevin Jones (26) | 4.0 | 2004-2008 | 2TM | |
| Thomas Jones (30) | 4.0 | 2000-2008 | 4TM | |
| Kevin Faulk (32) | 4.0 | 1999-2008 | nwe | |
| 43. | Rudi Johnson (29) | 3.9 | 2001-2008 | 2TM |
| T.J. Duckett (27) | 3.9 | 2002-2008 | 4TM | |
| Tony Richardson (37) | 3.9 | 1995-2008 | 3TM | |
| Willis McGahee (27) | 3.9 | 2004-2008 | 2TM | |
| Marshawn Lynch (22) | 3.9 | 2007-2008 | buf | |
| Reuben Droughns (30) | 3.9 | 2001-2008 | 4TM | |
| DeShaun Foster (28) | 3.9 | 2003-2008 | 2TM | |
| 50. | LenDale White (24) | 3.8 | 2006-2008 | oti |