| Rank | Player (age), + - HOFer, Bold - Active | Y/A | Years | Teams |
|---|---|---|---|---|
| 1. | Michael Vick (32) | 7.0 | 2001-2012 | 2TM |
| 2. | Jamaal Charles (26) | 5.8 | 2008-2012 | kan |
| 3. | Adrian Peterson (27) | 5.0 | 2007-2012 | min |
| 4. | DeAngelo Williams (29) | 4.9 | 2006-2012 | car |
| 5. | Felix Jones (25) | 4.8 | 2008-2012 | dal |
| Pierre Thomas (28) | 4.8 | 2007-2012 | nor | |
| 7. | Chris Johnson (27) | 4.7 | 2008-2012 | oti |
| Jonathan Stewart (25) | 4.7 | 2008-2012 | car | |
| Leon Washington (30) | 4.7 | 2006-2012 | 2TM | |
| 10. | LeSean McCoy (24) | 4.6 | 2009-2012 | phi |
| Maurice Jones-Drew (27) | 4.6 | 2006-2012 | jax | |
| Frank Gore (29) | 4.6 | 2005-2012 | sfo | |
| Ahmad Bradshaw (26) | 4.6 | 2007-2012 | nyg | |
| LeGarrette Blount (26) | 4.6 | 2010-2012 | tam | |
| 15. | Fred Jackson (31) | 4.5 | 2007-2012 | buf |
| Ray Rice (25) | 4.5 | 2008-2012 | rav | |
| Brandon Jacobs (30) | 4.5 | 2005-2012 | 2TM | |
| Michael Turner (30) | 4.5 | 2004-2012 | 2TM | |
| Arian Foster (26) | 4.5 | 2009-2012 | htx | |
| Mewelde Moore (30) | 4.5 | 2004-2012 | 3TM | |
| 21. | Ryan Mathews (25) | 4.4 | 2010-2012 | sdg |
| 22. | Ryan Grant (30) | 4.3 | 2007-2012 | 2TM |
| Darren McFadden (25) | 4.3 | 2008-2012 | rai | |
| Reggie Bush (27) | 4.3 | 2006-2012 | 2TM | |
| Ronnie Brown (31) | 4.3 | 2005-2012 | 3TM | |
| 26. | Steven Jackson (29) | 4.2 | 2004-2012 | ram |
| Marshawn Lynch (26) | 4.2 | 2007-2012 | 2TM | |
| Matt Forte (27) | 4.2 | 2008-2012 | chi | |
| Shonn Greene (27) | 4.2 | 2009-2012 | nyj | |
| 30. | Willis McGahee (31) | 4.1 | 2004-2012 | 3TM |
| Peyton Hillis (26) | 4.1 | 2008-2012 | 3TM | |
| Rashard Mendenhall (25) | 4.1 | 2008-2012 | pit | |
| Donald Brown (25) | 4.1 | 2009-2012 | clt | |
| Michael Bush (28) | 4.1 | 2008-2012 | 2TM | |
| 35. | Knowshon Moreno (25) | 4.0 | 2009-2012 | den |
| BenJarvus Green-Ellis (27) | 4.0 | 2008-2012 | 2TM | |
| Chris Wells (24) | 4.0 | 2009-2012 | crd | |
| 38. | Kevin Smith (26) | 3.9 | 2008-2012 | det |
| 39. | Cedric Benson (30) | 3.8 | 2005-2012 | 3TM |
| 40. | Tom Brady (35) | 1.9 | 2000-2012 | nwe |