| Rank | Player (age), + - HOFer, Bold - Active | Touch | Years | Teams |
|---|---|---|---|---|
| 1. | Edgerrin James (31) | 3,461 | 1999-2009 | 3TM |
| 2. | LaDainian Tomlinson (30) | 3,311 | 2001-2009 | sdg |
| 3. | Fred Taylor (33) | 2,761 | 1998-2009 | 2TM |
| 4. | Jamal Lewis (30) | 2,753 | 2000-2009 | 2TM |
| 5. | Ahman Green (32) | 2,476 | 1998-2009 | 3TM |
| 6. | Thomas Jones (31) | 2,442 | 2000-2009 | 4TM |
| 7. | Clinton Portis (28) | 2,418 | 2002-2009 | 2TM |
| 8. | Ricky Williams (32) | 2,345 | 1999-2009 | 2TM |
| 9. | Brian Westbrook (30) | 1,776 | 2002-2009 | phi |
| 10. | Steven Jackson (26) | 1,708 | 2004-2009 | ram |
| 11. | Willis McGahee (28) | 1,543 | 2004-2009 | 2TM |
| 12. | Larry Johnson (30) | 1,528 | 2003-2009 | 2TM |
| 13. | Kevin Faulk (33) | 1,506 | 1999-2009 | nwe |
| 14. | Willie Parker (29) | 1,306 | 2004-2009 | pit |
| 15. | Chester Taylor (30) | 1,300 | 2002-2009 | 2TM |
| 16. | Julius Jones (28) | 1,268 | 2004-2009 | 2TM |
| 17. | Frank Gore (26) | 1,252 | 2005-2009 | sfo |
| 18. | Derrick Mason (35) | 1,182 | 1997-2009 | 2TM |
| 19. | LaMont Jordan (31) | 1,084 | 2001-2009 | 4TM |
| 20. | Ronnie Brown (28) | 1,079 | 2005-2009 | mia |
| 21. | Isaac Bruce (37) | 1,049 | 1994-2009 | 2TM |
| 22. | Terrell Owens (36) | 1,029 | 1996-2009 | 4TM |
| 23. | Ladell Betts (30) | 1,027 | 2002-2009 | was |
| 24. | Marion Barber (26) | 1,007 | 2005-2009 | dal |
| 25. | Maurice Jones-Drew (24) | 994 | 2006-2009 | jax |
| 26. | Michael Bennett (31) | 982 | 2001-2009 | 4TM |
| 27. | Tony Gonzalez (33) | 970 | 1997-2009 | 2TM |
| 28. | Randy Moss (32) | 951 | 1998-2009 | 3TM |
| 29. | Joseph Addai (26) | 930 | 2006-2009 | clt |
| 30. | Hines Ward (33) | 928 | 1998-2009 | pit |
| 31. | Torry Holt (33) | 921 | 1999-2009 | 2TM |
| 32. | Joey Galloway (38) | 897 | 1995-2009 | 4TM |
| 33. | Cedric Benson (27) | 895 | 2005-2009 | 2TM |
| 34. | Justin Fargas (29) | 890 | 2003-2009 | rai |
| 35. | Adrian Peterson (24) | 888 | 2007-2009 | min |
| 36. | Maurice Morris (30) | 870 | 2002-2009 | 2TM |
| 37. | Steve Smith (30) | 868 | 2001-2009 | car |
| 38. | DeAngelo Williams (26) | 864 | 2006-2009 | car |
| 39. | Muhsin Muhammad (36) | 853 | 1996-2009 | 2TM |
| 40. | Michael Turner (27) | 835 | 2004-2009 | 2TM |
| 41. | Cadillac Williams (27) | 827 | 2005-2009 | tam |
| 42. | Allen Rossum (34) | 825 | 1998-2009 | 6TM |
| 43. | Sammy Morris (32) | 803 | 2000-2009 | 3TM |
| 44. | Brandon Jacobs (27) | 789 | 2005-2009 | nyg |
| 45. | Bobby Engram (36) | 787 | 1996-2009 | 3TM |
| Reggie Bush (24) | 787 | 2006-2009 | nor | |
| 47. | Antwaan Randle El (30) | 781 | 2002-2009 | 2TM |
| 48. | Ryan Grant (27) | 780 | 2007-2009 | gnb |
| 49. | Chris Brown (28) | 779 | 2003-2009 | 2TM |
| 50. | Wes Welker (28) | 777 | 2004-2009 | 3TM |