Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Colin Kaepernick | 29 | 5 | 11 | 196 for 331, 2,241 yards, 16 td, 4 int, & 69 rushes for 468 yards and 2 td | |
| RB | Carlos Hyde | 26 | 2 | 13 | 217 rushes for 988 yards, 6 td, & 27 catches for 163 yards and 3 td | |
| WR | Jeremy Kerley | 28 | 5 | 13 | 64 catches for 667 yards, 3 td | |
| WR | Vance McDonald | 26 | 3 | 11 | 24 catches for 391 yards, 4 td | |
| WR | Quinton Patton | 26 | 3 | 14 | 37 catches for 408 yards, 0 td | |
| WR | Torrey Smith | 27 | 5 | 12 | 20 catches for 267 yards, 3 td | |
| LT | Joe Staley | 32 | 9 | 13 | ||
| LG | Zane Beadles | 30 | 6 | 16 | 1 fumble recovered | |
| C | Daniel Kilgore | 29 | 5 | 13 | ||
| RG | Joshua Garnett | 22 | Rook | 11 | 3 fumbles recovered | |
| RT | Trent Brown | 23 | 1 | 16 | 1 fumble recovered | |
| Defensive Starters | ||||||
| LDE | DeForest Buckner | 22 | Rook | 15 | 6.0 sacks, 0 interceptions, 2 fumbles recovered | |
| NT | Glenn Dorsey | 31 | 8 | 7 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Quinton Dial | 26 | 3 | 11 | ||
| LOLB | Ahmad Brooks | 32 | 10 | 16 | 6.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Nick Bellore | 27 | 5 | 10 | 1.0 sacks, 1 interception, 1 fumble recovered | |
| RILB | Gerald Hodges | 25 | 3 | 12 | 3.0 sacks, 2 interceptions, 1 fumble recovered | |
| ROLB | Eli Harold | 22 | 1 | 13 | 3.0 sacks, 0 interceptions, 1 fumble recovered | |
| LCB | Tramaine Brock | 28 | 6 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Jimmie Ward | 25 | 2 | 10 | 1.0 sacks, 1 interception, 1 fumble recovered | |
| SS | Antoine Bethea | 32 | 10 | 16 | 0.0 sacks, 1 interception, 1 fumble recovered | |
| FS | Eric Reid | 25 | 3 | 10 | 0.0 sacks, 1 interception, 0 fumbles recovered |
Roster