| Offensive Starters | | | | | |
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| QB | Josh Allen* | 29 | 7 | 17 | 319 for 460, 3,668 yards, 25 td, 10 int, & 112 rushes for 579 yards and 14 td | |
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| RB | James Cook* | 26 | 3 | 17 | 309 rushes for 1,621 yards, 12 td, & 33 catches for 291 yards and 2 td | |
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| WR | Keon Coleman | 22 | 1 | 6 | 38 catches for 404 yards, 4 td | |
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| WR | Josh Palmer | 26 | 4 | 8 | 22 catches for 303 yards, 0 td | |
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| WR | Khalil Shakir | 25 | 3 | 10 | 72 catches for 719 yards, 4 td, & 1 rush for 5 yards and 0 td | |
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| TE | Dawson Knox | 29 | 6 | 12 | 36 catches for 417 yards, 4 td | |
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| LT | Dion Dawkins* | 31 | 8 | 15 | | |
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| LG | David Edwards | 28 | 6 | 16 | | |
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| C | Connor McGovern | 28 | 5 | 16 | | |
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| RG | O'Cyrus Torrence | 25 | 2 | 17 | | |
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| RT | Spencer Brown | 27 | 4 | 13 | 1 fumble recovered | |
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| Defensive Starters | | | | | |
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| DE | Joey Bosa | 30 | 9 | 15 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| DE | Gregory Rousseau | 25 | 4 | 16 | 7.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| DT | DaQuan Jones | 34 | 11 | 12 | 3.0 sacks, 1 interception, 0 fumbles recovered | |
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| DT | Deone Walker | 21 | Rook | 16 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
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| LB | Terrel Bernard | 26 | 3 | 11 | 0.0 sacks, 1 interception, 2 fumbles recovered | |
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| LB | Matt Milano | 31 | 8 | 12 | 3.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LB | Dorian Williams | 24 | 2 | 9 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| CB | Christian Benford | 25 | 3 | 14 | 2.0 sacks, 2 interceptions, 2 fumbles recovered | |
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| CB | Tre'Davious White | 30 | 8 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| S | Cole Bishop | 23 | 1 | 17 | 2.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| S | Jordan Poyer | 34 | 12 | 9 | 0.5 sacks, 1 interception, 0 fumbles recovered | |
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Roster