| Offensive Starters | | | | | |
| QB | Kyle Orton | 26 | 3 | 15 | 272 for 465, 2,972 yards, 18 td, 12 int, & 24 rushes for 49 yards and 3 td | |
| RB | Matt Forte | 23 | Rook | 16 | 316 rushes for 1,238 yards, 8 td, & 63 catches for 477 yards and 4 td | |
| FB | Jason McKie | 28 | 6 | 8 | 11 rushes for 26 yards, 2 td, & 11 catches for 64 yards and 1 td | |
| WR | Rashied Davis | 29 | 3 | 12 | 35 catches for 445 yards, 2 td, & 3 rushes for 14 yards and 0 td | |
| WR | Devin Hester | 26 | 2 | 8 | 51 catches for 665 yards, 3 td, & 6 rushes for 61 yards and 0 td | |
| TE | Desmond Clark | 31 | 9 | 16 | 41 catches for 367 yards, 1 td | |
| LT | John St. Clair | 31 | 6 | 16 | | |
| LG | Josh Beekman | 25 | 1 | 16 | | |
| C | Olin Kreutz | 31 | 10 | 16 | | |
| RG | Roberto Garza | 29 | 7 | 16 | | |
| RT | John Tait | 33 | 9 | 16 | | |
| Defensive Starters | | | | | |
| LDE | Adewale Ogunleye | 31 | 7 | 16 | 5.0 sacks, 1 interception, 0 fumbles recovered | |
| LDT | Tommie Harris | 25 | 4 | 13 | 5.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDT | Dusty Dvoracek | 27 | 1 | 12 | | |
| RDE | Alex Brown | 29 | 6 | 16 | 6.0 sacks, 1 interception, 1 fumble recovered | |
| LLB | Nick Roach | 23 | 1 | 9 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| MLB | Brian Urlacher | 30 | 8 | 16 | 0.0 sacks, 2 interceptions, 1 fumble recovered | |
| RLB | Lance Briggs* | 28 | 5 | 16 | 0.5 sacks, 3 interceptions, 2 fumbles recovered | |
| LCB | Charles Tillman | 27 | 5 | 15 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
| RCB | Corey Graham | 23 | 1 | 9 | 0.0 sacks, 1 interception, 1 fumble recovered | |
| SS | Kevin Payne | 25 | 1 | 16 | 1.0 sacks, 4 interceptions, 0 fumbles recovered | |
| FS | Mike Brown | 30 | 8 | 15 | 1.0 sacks, 2 interceptions, 0 fumbles recovered | |
Roster