| Offensive Starters | | | | | |
| QB | Joe Burrow* | 28 | 4 | 17 | 460 for 652, 4,918 yards, 43 td, 9 int, & 42 rushes for 201 yards and 2 td | |
| RB | Chase Brown | 24 | 1 | 10 | 229 rushes for 990 yards, 7 td, & 54 catches for 360 yards and 4 td | |
| WR | Ja'Marr Chase*+ | 24 | 3 | 16 | 127 catches for 1,708 yards, 17 td, & 3 rushes for 32 yards and 0 td | |
| WR | Tee Higgins | 25 | 4 | 9 | 73 catches for 911 yards, 10 td | |
| TE | Cam Grandy | 24 | Rook | 6 | 5 catches for 28 yards, 0 td | |
| TE | Drew Sample | 28 | 5 | 15 | 20 catches for 109 yards, 1 td, & 1 rush for -4 yards and 0 td | |
| LT | Orlando Brown Jr. | 28 | 6 | 11 | | |
| LG | Cordell Volson | 26 | 2 | 15 | | |
| C | Ted Karras | 31 | 8 | 17 | | |
| RG | Alex Cappa | 29 | 6 | 17 | | |
| RT | Amarius Mims | 22 | Rook | 13 | | |
| Defensive Starters | | | | | |
| LDE | Sam Hubbard | 29 | 6 | 14 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| LDT | Kris Jenkins | 23 | Rook | 9 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDT | B.J. Hill | 29 | 6 | 15 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Trey Hendrickson*+ | 30 | 7 | 17 | 17.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LLB | Logan Wilson | 28 | 4 | 11 | 0.0 sacks, 0 interceptions, 2 fumbles recovered | |
| MLB | Germaine Pratt | 28 | 5 | 17 | 0.0 sacks, 2 interceptions, 2 fumbles recovered | |
| RLB | Akeem Davis-Gaither | 27 | 4 | 7 | 0.0 sacks, 1 interception, 1 fumble recovered | |
| LCB | Cam Taylor-Britt | 25 | 2 | 17 | 0.5 sacks, 3 interceptions, 0 fumbles recovered | |
| RCB | Josh Newton | 24 | Rook | 6 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| SS | Geno Stone | 25 | 4 | 17 | 0.0 sacks, 4 interceptions, 1 fumble recovered | |
| FS | Vonn Bell | 30 | 8 | 11 | 0.0 sacks, 1 interception, 1 fumble recovered | |
Roster