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- March 17, 2018: Traded 2018 1st round pick (3rd overall, Sam Darnold) to Jets for 2018 1st round pick (6th overall, Quenton Nelson), 2018 2nd round pick (37th overall, Braden Smith), 2018 2nd round pick (49th overall subsequently traded, Dallas Goedert) and 2019 2nd round pick (34th overall, Rock Ya-Sin)
- April 27, 2018: Traded 2018 2nd round pick (49th overall, Dallas Goedert) to Eagles for 2018 2nd round pick (52nd overall, Kemoko Turay) and 2018 5th round pick (169th overall, Jordan Wilkins)
- April 27, 2018: Traded 2018 3rd round pick (67th overall, Chad Thomas) and 2018 6th round pick (178th overall subsequently traded, Christian Sam) to Browns for 2018 2nd round pick (64th overall, Tyquan Lewis)
- April 28, 2018: Traded Henry Anderson to Jets for 2018 7th round pick (235th overall, Zaire Franklin)
- April 28, 2018: Traded 2018 5th round pick (140th overall, Maurice Hurst) to Raiders for 2018 5th round pick (159th overall, Daurice Fountain) and 2018 6th round pick (185th overall, Deon Cain)
- August 26, 2018: Traded Antonio Morrison to Packers for Lenzy Pipkins
- September 1, 2018: Traded Marcus Johnson to Seahawks for Darrell Daniels