| Offensive Starters | | | | | |
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| QB | Jacoby Brissett | 27 | 3 | 15 | 272 for 447, 2,942 yards, 18 td, 6 int, & 56 rushes for 228 yards and 4 td | New England Patriots / 3rd / 91st pick / 2016 |
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| RB | Marlon Mack | 23 | 2 | 12 | 247 rushes for 1,091 yards, 8 td, & 14 catches for 82 yards and 0 td | Indianapolis Colts / 4th / 143rd pick / 2017 |
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| WR | T.Y. Hilton | 30 | 7 | 10 | 45 catches for 501 yards, 5 td | Indianapolis Colts / 3rd / 92nd pick / 2012 |
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| WR | Marcus Johnson | 25 | 2 | 6 | 17 catches for 277 yards, 2 td | |
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| WR | Zach Pascal | 25 | 1 | 13 | 41 catches for 607 yards, 5 td, & 2 rushes for 16 yards and 0 td | |
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| TE | Jack Doyle* | 29 | 6 | 16 | 43 catches for 448 yards, 4 td | |
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| LT | Anthony Castonzo | 31 | 8 | 16 | | Indianapolis Colts / 1st / 22nd pick / 2011 |
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| LG | Quenton Nelson*+ | 23 | 1 | 16 | | Indianapolis Colts / 1st / 6th pick / 2018 |
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| C | Ryan Kelly* | 26 | 3 | 16 | | Indianapolis Colts / 1st / 18th pick / 2016 |
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| RG | Mark Glowinski | 27 | 4 | 16 | 1 fumble recovered | Seattle Seahawks / 4th / 134th pick / 2015 |
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| RT | Braden Smith | 23 | 1 | 16 | | Indianapolis Colts / 2nd / 37th pick / 2018 |
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| Defensive Starters | | | | | |
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| LDE | Justin Houston | 30 | 8 | 16 | 11.0 sacks, 0 interceptions, 3 fumbles recovered | Kansas City Chiefs / 3rd / 70th pick / 2011 |
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| DE | Jabaal Sheard | 30 | 8 | 12 | | Cleveland Browns / 2nd / 37th pick / 2011 |
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| LDT | Grover Stewart | 26 | 2 | 13 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | Indianapolis Colts / 4th / 144th pick / 2017 |
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| DT | Denico Autry | 29 | 5 | 14 | | |
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| RDE | Jabaal Sheard | 30 | 8 | 12 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | Cleveland Browns / 2nd / 37th pick / 2011 |
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| LLB | Darius Leonard* | 24 | 1 | 13 | 5.0 sacks, 5 interceptions, 0 fumbles recovered | Indianapolis Colts / 2nd / 36th pick / 2018 |
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| MLB | Anthony Walker | 24 | 2 | 16 | 2.5 sacks, 1 interception, 0 fumbles recovered | Indianapolis Colts / 5th / 161st pick / 2017 |
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| RLB | Bobby Okereke | 23 | Rook | 8 | 1.0 sacks, 0 interceptions, 1 fumble recovered | Indianapolis Colts / 3rd / 89th pick / 2019 |
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| LCB | Kenny Moore | 24 | 2 | 11 | 2.5 sacks, 2 interceptions, 1 fumble recovered | |
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| CB | Pierre Desir | 29 | 5 | 11 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | Cleveland Browns / 4th / 127th pick / 2014 |
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| RCB | Pierre Desir | 29 | 5 | 11 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | Cleveland Browns / 4th / 127th pick / 2014 |
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| SS | Clayton Geathers | 27 | 4 | 10 | 0.0 sacks, 1 interception, 0 fumbles recovered | Indianapolis Colts / 4th / 109th pick / 2015 |
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| FS | Malik Hooker | 23 | 2 | 13 | 0.0 sacks, 2 interceptions, 1 fumble recovered | Indianapolis Colts / 1st / 15th pick / 2017 |
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