| Offensive Starters | | | | | |
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| QB | Philip Rivers | 39 | 16 | 16 | 369 for 543, 4,169 yards, 24 td, 11 int, & 18 rushes for -8 yards and 0 td | New York Giants / 1st / 4th pick / 2004 |
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| RB | Jonathan Taylor | 21 | Rook | 13 | 232 rushes for 1,169 yards, 11 td, & 36 catches for 299 yards and 1 td | Indianapolis Colts / 2nd / 41st pick / 2020 |
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| WR | T.Y. Hilton | 31 | 8 | 15 | 56 catches for 762 yards, 5 td | Indianapolis Colts / 3rd / 92nd pick / 2012 |
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| WR | Zach Pascal | 26 | 2 | 14 | 44 catches for 629 yards, 5 td | |
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| TE | Jack Doyle | 30 | 7 | 12 | 23 catches for 251 yards, 3 td | |
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| T | Anthony Castonzo | 32 | 9 | 12 | | Indianapolis Colts / 1st / 22nd pick / 2011 |
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| T | Braden Smith | 24 | 2 | 14 | | Indianapolis Colts / 2nd / 37th pick / 2018 |
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| G | Mark Glowinski | 28 | 5 | 16 | | Seattle Seahawks / 4th / 134th pick / 2015 |
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| G | Quenton Nelson*+ | 24 | 2 | 16 | | Indianapolis Colts / 1st / 6th pick / 2018 |
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| C | Ryan Kelly* | 27 | 4 | 15 | | Indianapolis Colts / 1st / 18th pick / 2016 |
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| Defensive Starters | | | | | |
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| DE | Denico Autry | 30 | 6 | 13 | | |
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| DE | Justin Houston | 31 | 9 | 16 | | Kansas City Chiefs / 3rd / 70th pick / 2011 |
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| DT | DeForest Buckner + | 26 | 4 | 14 | | San Francisco 49ers / 1st / 7th pick / 2016 |
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| NT | Grover Stewart | 27 | 3 | 16 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | Indianapolis Colts / 4th / 144th pick / 2017 |
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| MLB | Darius Leonard*+ | 25 | 2 | 14 | 3.0 sacks, 0 interceptions, 2 fumbles recovered | Indianapolis Colts / 2nd / 36th pick / 2018 |
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| MLB | Anthony Walker | 25 | 3 | 16 | 0.0 sacks, 1 interception, 1 fumble recovered | Indianapolis Colts / 5th / 161st pick / 2017 |
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| CB | Kenny Moore | 25 | 3 | 14 | 2.0 sacks, 4 interceptions, 0 fumbles recovered | |
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| CB | Xavier Rhodes | 30 | 7 | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | Minnesota Vikings / 1st / 25th pick / 2013 |
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| SS | Khari Willis | 24 | 1 | 14 | 2.0 sacks, 2 interceptions, 0 fumbles recovered | Indianapolis Colts / 4th / 109th pick / 2019 |
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| FS | Julian Blackmon | 22 | Rook | 14 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | Indianapolis Colts / 3rd / 85th pick / 2020 |
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Roster