| Offensive Starters | | | | | |
|---|
| QB | Matt Leinart | 23 | Rook | 11 | 214 for 377, 2,547 yards, 11 td, 12 int, & 22 rushes for 49 yards and 2 td | |
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| RB | Edgerrin James | 28 | 7 | 16 | 337 rushes for 1,159 yards, 6 td, & 38 catches for 217 yards and 0 td | |
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| WR | Anquan Boldin* | 26 | 3 | 16 | 83 catches for 1,203 yards, 4 td, & 5 rushes for 28 yards and 0 td | |
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| WR | Larry Fitzgerald | 23 | 2 | 13 | 69 catches for 946 yards, 6 td | |
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| WR | Bryant Johnson | 25 | 3 | 8 | 40 catches for 740 yards, 4 td, & 1 rush for -3 yards and 0 td | |
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| TE | Fred Wakefield | 28 | 5 | 9 | 2 catches for 24 yards, 0 td | |
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| LT | Leonard Davis | 28 | 5 | 16 | | |
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| LG | Milford Brown | 26 | 3 | 12 | 2 fumbles recovered | |
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| C | Nick Leckey | 24 | 2 | 11 | | |
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| RG | Deuce Lutui | 23 | Rook | 9 | 1 fumble recovered | |
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| RT | Reggie Wells | 26 | 3 | 16 | | |
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| Defensive Starters | | | | | |
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| LDE | Chike Okeafor | 30 | 7 | 15 | 8.5 sacks, 0 interceptions, 2 fumbles recovered | |
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| LDT | Kendrick Clancy | 28 | 6 | 11 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | Darnell Dockett | 25 | 2 | 16 | 2.0 sacks, 1 interception, 2 fumbles recovered | |
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| RDE | Bertrand Berry | 31 | 9 | 10 | 6.0 sacks, 0 interceptions, 1 fumble recovered | |
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| LLB | Karlos Dansby | 25 | 2 | 10 | 8.0 sacks, 0 interceptions, 1 fumble recovered | |
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| MLB | Gerald Hayes | 26 | 3 | 14 | 1.0 sacks, 3 interceptions, 2 fumbles recovered | |
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| RLB | Orlando Huff | 28 | 5 | 13 | | |
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| LCB | Antrel Rolle | 24 | 1 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| RCB | Eric Green | 24 | 1 | 8 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| SS | Adrian Wilson* | 27 | 5 | 16 | 5.0 sacks, 4 interceptions, 2 fumbles recovered | |
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| FS | Robert Griffith | 36 | 12 | 16 | 0.0 sacks, 3 interceptions, 1 fumble recovered | |
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Roster