| Offensive Starters | | | | | |
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| QB | Kyler Murray | 22 | Rook | 16 | 349 for 542, 3,722 yards, 20 td, 12 int, & 93 rushes for 544 yards and 4 td | Arizona Cardinals / 1st / 1st pick / 2019 |
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| RB | Kenyan Drake | 25 | 3 | 8 | 123 rushes for 643 yards, 8 td, & 28 catches for 171 yards and 0 td | Miami Dolphins / 3rd / 73rd pick / 2016 |
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| WR | Larry Fitzgerald | 36 | 15 | 16 | 75 catches for 804 yards, 4 td | Arizona Cardinals / 1st / 3rd pick / 2004 |
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| WR | Christian Kirk | 23 | 1 | 13 | 68 catches for 709 yards, 3 td, & 10 rushes for 93 yards and 0 td | Arizona Cardinals / 2nd / 47th pick / 2018 |
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| TE | Charles Clay | 30 | 8 | 10 | 18 catches for 237 yards, 1 td | Miami Dolphins / 6th / 174th pick / 2011 |
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| TE | Maxx Williams | 25 | 4 | 10 | 15 catches for 202 yards, 1 td | Baltimore Ravens / 2nd / 55th pick / 2015 |
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| LT | D.J. Humphries | 26 | 3 | 16 | | Arizona Cardinals / 1st / 24th pick / 2015 |
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| LG | Justin Pugh | 29 | 6 | 16 | | New York Giants / 1st / 19th pick / 2013 |
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| C | A.Q. Shipley | 33 | 10 | 16 | | Pittsburgh Steelers / 7th / 226th pick / 2009 |
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| RG | J.R. Sweezy | 30 | 7 | 16 | | Seattle Seahawks / 7th / 225th pick / 2012 |
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| RT | Justin Murray | 26 | 1 | 12 | | |
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| Defensive Starters | | | | | |
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| LDE | Jonathan Bullard | 26 | 3 | 6 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | Chicago Bears / 3rd / 72nd pick / 2016 |
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| DE | Rodney Gunter | 27 | 4 | 13 | | Arizona Cardinals / 4th / 116th pick / 2015 |
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| NT | Corey Peters | 31 | 9 | 16 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | Atlanta Falcons / 3rd / 83rd pick / 2010 |
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| RDE | Rodney Gunter | 27 | 4 | 13 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | Arizona Cardinals / 4th / 116th pick / 2015 |
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| LOLB | Chandler Jones*+ | 29 | 7 | 16 | 19.0 sacks, 0 interceptions, 3 fumbles recovered | New England Patriots / 1st / 21st pick / 2012 |
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| LILB | Joe Walker | 27 | 2 | 11 | | Philadelphia Eagles / 7th / 251st pick / 2016 |
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| RILB | Jordan Hicks | 27 | 4 | 16 | 1.5 sacks, 3 interceptions, 1 fumble recovered | Philadelphia Eagles / 3rd / 84th pick / 2015 |
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| ROLB | Terrell Suggs | 37 | 16 | 13 | 5.5 sacks, 0 interceptions, 1 fumble recovered | Baltimore Ravens / 1st / 10th pick / 2003 |
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| LCB | Byron Murphy | 21 | Rook | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | Arizona Cardinals / 2nd / 33rd pick / 2019 |
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| RCB | Patrick Peterson | 29 | 8 | 10 | 1.0 sacks, 2 interceptions, 0 fumbles recovered | Arizona Cardinals / 1st / 5th pick / 2011 |
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| SS | Jalen Thompson | 21 | Rook | 9 | 0.0 sacks, 1 interception, 1 fumble recovered | Arizona Cardinals / 5th / 1st pick / 2019 Supp |
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| FS | Budda Baker * | 23 | 2 | 16 | 0.5 sacks, 0 interceptions, 1 fumble recovered | Arizona Cardinals / 2nd / 36th pick / 2017 |
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Roster