| Offensive Starters | | | | | |
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| QB | Kyler Murray* | 23 | 1 | 16 | 375 for 558, 3,971 yards, 26 td, 12 int, & 133 rushes for 819 yards and 11 td | |
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| RB | Kenyan Drake | 26 | 4 | 13 | 239 rushes for 955 yards, 10 td, & 25 catches for 137 yards and 0 td | |
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| WR | Larry Fitzgerald | 37 | 16 | 13 | 54 catches for 409 yards, 1 td | |
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| WR | DeAndre Hopkins* | 28 | 7 | 16 | 115 catches for 1,407 yards, 6 td, & 1 rush for 1 yards and 0 td | |
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| WR | Christian Kirk | 24 | 2 | 10 | 48 catches for 621 yards, 6 td, & 2 rushes for 3 yards and 0 td | |
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| TE | Maxx Williams | 26 | 5 | 8 | 8 catches for 102 yards, 1 td | |
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| LT | D.J. Humphries | 27 | 4 | 16 | | |
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| LG | Justin Pugh | 30 | 7 | 15 | | |
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| C | Mason Cole | 24 | 2 | 14 | 1 fumble recovered | |
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| RG | J.R. Sweezy | 31 | 8 | 10 | | |
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| RT | Kelvin Beachum | 31 | 8 | 16 | 1 fumble recovered | |
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| Defensive Starters | | | | | |
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| LDT | Zach Allen | 23 | 1 | 7 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| NT | Corey Peters | 32 | 10 | 9 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | Jordan Phillips | 28 | 5 | 9 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
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| LOLB | Haason Reddick | 26 | 3 | 11 | 12.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LILB | De'Vondre Campbell | 27 | 4 | 16 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RILB | Jordan Hicks | 28 | 5 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| ROLB | Markus Golden | 29 | 5 | 8 | 3.0 sacks, 1 interception, 1 fumble recovered | |
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| LCB | Patrick Peterson | 30 | 9 | 16 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| RCB | Dre Kirkpatrick | 31 | 8 | 11 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| SS | Budda Baker*+ | 24 | 3 | 15 | 2.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| FS | Jalen Thompson | 22 | 1 | 4 | | |
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Roster