| Offensive Starters | | | | | |
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| QB | Kyler Murray * | 23 | 1 | 16 | 375 for 558, 3,971 yards, 26 td, 12 int, & 133 rushes for 819 yards and 11 td | Arizona Cardinals / 1st / 1st pick / 2019 |
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| RB | Kenyan Drake | 26 | 4 | 13 | 239 rushes for 955 yards, 10 td, & 25 catches for 137 yards and 0 td | Miami Dolphins / 3rd / 73rd pick / 2016 |
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| WR | Larry Fitzgerald | 37 | 16 | 13 | 54 catches for 409 yards, 1 td | Arizona Cardinals / 1st / 3rd pick / 2004 |
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| WR | DeAndre Hopkins* | 28 | 7 | 16 | 115 catches for 1,407 yards, 6 td, & 1 rush for 1 yards and 0 td | Houston Texans / 1st / 27th pick / 2013 |
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| WR | Christian Kirk | 24 | 2 | 10 | 48 catches for 621 yards, 6 td, & 2 rushes for 3 yards and 0 td | Arizona Cardinals / 2nd / 47th pick / 2018 |
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| T | Kelvin Beachum | 31 | 8 | 16 | | Pittsburgh Steelers / 7th / 248th pick / 2012 |
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| T | D.J. Humphries | 27 | 4 | 16 | | Arizona Cardinals / 1st / 24th pick / 2015 |
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| G | Justin Pugh | 30 | 7 | 15 | | New York Giants / 1st / 19th pick / 2013 |
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| G | J.R. Sweezy | 31 | 8 | 10 | | Seattle Seahawks / 7th / 225th pick / 2012 |
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| C | Mason Cole | 24 | 2 | 14 | 1 fumble recovered | Arizona Cardinals / 3rd / 97th pick / 2018 |
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| Defensive Starters | | | | | |
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| OLB | Haason Reddick | 26 | 3 | 11 | | Arizona Cardinals / 1st / 13th pick / 2017 |
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| ILB | De'Vondre Campbell | 27 | 4 | 16 | | Atlanta Falcons / 4th / 115th pick / 2016 |
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| ILB | Jordan Hicks | 28 | 5 | 16 | | Philadelphia Eagles / 3rd / 84th pick / 2015 |
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| CB | Dre Kirkpatrick | 31 | 8 | 11 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | Cincinnati Bengals / 1st / 17th pick / 2012 |
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| CB | Patrick Peterson | 30 | 9 | 16 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | Arizona Cardinals / 1st / 5th pick / 2011 |
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| SS | Budda Baker * | 24 | 3 | 15 | 2.0 sacks, 2 interceptions, 0 fumbles recovered | Arizona Cardinals / 2nd / 36th pick / 2017 |
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Roster