Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Matt Schaub | 29 | 6 | 16 | 365 for 574, 4,370 yards, 24 td, 12 int, & 22 rushes for 28 yards and 0 td | |
| RB | Arian Foster*+ | 24 | 1 | 13 | 327 rushes for 1,616 yards, 16 td, & 66 catches for 604 yards and 2 td | |
| WR | Andre Johnson* | 29 | 7 | 13 | 86 catches for 1,216 yards, 8 td, & 2 rushes for 10 yards and 0 td | |
| WR | Kevin Walter | 29 | 7 | 16 | 51 catches for 621 yards, 5 td | |
| TE | Owen Daniels | 28 | 4 | 10 | 38 catches for 471 yards, 2 td | |
| TE | Joel Dreessen | 28 | 5 | 10 | 36 catches for 518 yards, 4 td | |
| LT | Duane Brown | 25 | 2 | 12 | ||
| LG | Wade Smith | 29 | 7 | 16 | 1 fumble recovered | |
| C | Chris Myers | 29 | 5 | 16 | ||
| RG | Mike Brisiel | 27 | 3 | 9 | ||
| RT | Eric Winston | 27 | 4 | 16 | 2 fumbles recovered | |
| Defensive Starters | ||||||
| LDE | Antonio Smith | 29 | 6 | 16 | 4.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Shaun Cody | 27 | 5 | 16 | ||
| RDT | Amobi Okoye | 23 | 3 | 16 | 3.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Mario Williams | 25 | 4 | 13 | 8.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LLB | Brian Cushing | 23 | 1 | 12 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | |
| MLB | Kevin Bentley | 31 | 8 | 8 | 0.0 sacks, 1 interception, 1 fumble recovered | |
| RLB | Zach Diles | 25 | 3 | 10 | ||
| LCB | Glover Quin | 24 | 1 | 16 | 0.0 sacks, 3 interceptions, 2 fumbles recovered | |
| RCB | Kareem Jackson | 22 | Rook | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| SS | Bernard Pollard | 26 | 4 | 15 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | |
| FS | Eugene Wilson | 30 | 7 | 13 |

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