| Offensive Starters | | | | | |
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| QB | Deshaun Watson * | 24 | 2 | 15 | 333 for 495, 3,852 yards, 26 td, 12 int, & 82 rushes for 413 yards and 7 td | Houston Texans / 1st / 12th pick / 2017 |
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| RB | Carlos Hyde | 29 | 5 | 14 | 245 rushes for 1,070 yards, 6 td, & 10 catches for 42 yards and 0 td | San Francisco 49ers / 2nd / 57th pick / 2014 |
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| WR | Will Fuller | 25 | 3 | 11 | 49 catches for 670 yards, 3 td | Houston Texans / 1st / 21st pick / 2016 |
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| WR | DeAndre Hopkins*+ | 27 | 6 | 15 | 104 catches for 1,165 yards, 7 td, & 2 rushes for 18 yards and 0 td | Houston Texans / 1st / 27th pick / 2013 |
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| TE | Jordan Akins | 27 | 1 | 9 | 36 catches for 418 yards, 2 td | Houston Texans / 3rd / 98th pick / 2018 |
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| TE | Darren Fells | 33 | 6 | 14 | 34 catches for 341 yards, 7 td | |
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| LT | Laremy Tunsil* | 25 | 3 | 14 | | Miami Dolphins / 1st / 13th pick / 2016 |
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| LG | Max Scharping | 23 | Rook | 14 | 1 fumble recovered | Houston Texans / 2nd / 55th pick / 2019 |
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| C | Nick Martin | 26 | 2 | 16 | | Houston Texans / 2nd / 50th pick / 2016 |
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| RG | Zach Fulton | 28 | 5 | 15 | | Kansas City Chiefs / 6th / 193rd pick / 2014 |
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| RT | Tytus Howard | 23 | Rook | 8 | 1 fumble recovered | Houston Texans / 1st / 23rd pick / 2019 |
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| Defensive Starters | | | | | |
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| LDE | J.J. Watt | 30 | 8 | 8 | 4.0 sacks, 0 interceptions, 2 fumbles recovered | Houston Texans / 1st / 11th pick / 2011 |
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| NT | D.J. Reader | 25 | 3 | 15 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | Houston Texans / 5th / 166th pick / 2016 |
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| RDE | Angelo Blackson | 27 | 4 | 15 | | Tennessee Titans / 4th / 100th pick / 2015 |
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| LOLB | Whitney Mercilus | 29 | 7 | 16 | 7.5 sacks, 2 interceptions, 1 fumble recovered | Houston Texans / 1st / 26th pick / 2012 |
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| LILB | Benardrick McKinney | 27 | 4 | 14 | 1.0 sacks, 0 interceptions, 2 fumbles recovered | Houston Texans / 2nd / 43rd pick / 2015 |
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| RILB | Zach Cunningham | 25 | 2 | 16 | 2.0 sacks, 0 interceptions, 2 fumbles recovered | Houston Texans / 2nd / 57th pick / 2017 |
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| ROLB | Brennan Scarlett | 26 | 3 | 10 | 3.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LCB | Johnathan Joseph | 35 | 13 | 11 | 0.0 sacks, 1 interception, 0 fumbles recovered | Cincinnati Bengals / 1st / 24th pick / 2006 |
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| CB | Johnathan Joseph | 35 | 13 | 11 | 0.0 sacks, 1 interception, 0 fumbles recovered | Cincinnati Bengals / 1st / 24th pick / 2006 |
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| RCB | Bradley Roby | 27 | 5 | 10 | 1.0 sacks, 2 interceptions, 0 fumbles recovered | Denver Broncos / 1st / 31st pick / 2014 |
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| SS | Tashaun Gipson | 29 | 7 | 14 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| FS | Justin Reid | 22 | 1 | 15 | 0.0 sacks, 2 interceptions, 1 fumble recovered | Houston Texans / 3rd / 68th pick / 2018 |
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