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- March 14, 2018: Traded Marcus Peters and 2018 6th round pick (209th overall subsequently traded, Cornell Armstrong) to Rams for 2018 4th round pick (124th overall, Armani Watts) and 2019 2nd round pick (63rd overall, Juan Thornhill)
- March 14, 2018: Traded Alex Smith to Redskins for Kendall Fuller and 2018 3rd round pick (78th overall subsequently traded, Malik Jefferson)
- April 27, 2018: Traded 2018 3rd round pick (86th overall, Mark Andrews) and 2018 4th round pick (122nd overall, Kenny Young) to Ravens for 2018 3rd round pick (75th overall, Derrick Nnadi)
- April 27, 2018: Traded 2018 2nd round pick (54th overall, Jessie Bates) and 2018 3rd round pick (78th overall, Malik Jefferson) to Bengals for 2018 2nd round pick (46th overall, Breeland Speaks) and 2018 3rd round pick (100th overall, Dorian O'Daniel)
- April 28, 2018: Traded 2018 7th round pick (233rd overall subsequently traded, Jordan Mailata) and 2018 7th round pick (243rd overall, Keion Crossen) to Patriots for 2018 6th round pick (198th overall, Kahlil McKenzie)
- August 30, 2018: Traded Parker Ehinger to Cowboys for Charvarius Ward
- August 31, 2018: Traded Jordan Lucas to Dolphins for a 2020 7th round pick