Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Derek Carr | 33 | 10 | 10 | 189 for 279, 2,145 yards, 15 td, 5 int, & 17 rushes for 71 yards and 1 td | |
| RB | Alvin Kamara | 29 | 7 | 14 | 228 rushes for 950 yards, 6 td, & 68 catches for 543 yards and 2 td | |
| WR | Chris Olave | 24 | 2 | 8 | 32 catches for 400 yards, 1 td, & 1 rush for 7 yards and 0 td | |
| TE | Taysom Hill | 34 | 7 | 8 | 23 catches for 187 yards, 0 td, & 39 rushes for 278 yards and 6 td | |
| TE | Juwan Johnson | 28 | 4 | 5 | 50 catches for 548 yards, 3 td | |
| TE | Foster Moreau | 27 | 5 | 17 | 32 catches for 413 yards, 5 td | |
| LT | Taliese Fuaga | 22 | Rook | 17 | 1 fumble recovered | |
| LG | Lucas Patrick | 31 | 7 | 10 | ||
| C | Erik McCoy* | 27 | 5 | 7 | ||
| RG | Cesar Ruiz | 25 | 4 | 13 | ||
| RT | Trevor Penning | 25 | 2 | 17 | ||
| Defensive Starters | ||||||
| LDE | Cameron Jordan | 35 | 13 | 17 | 4.0 sacks, 1 interception, 0 fumbles recovered | |
| LDT | Khalen Saunders | 28 | 5 | 10 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| RDT | Nathan Shepherd | 31 | 6 | 13 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Carl Granderson | 28 | 5 | 17 | 5.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LLB | Pete Werner | 25 | 3 | 13 | ||
| MLB | Demario Davis | 35 | 12 | 16 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| RLB | Willie Gay Jr. | 26 | 4 | 8 | 2.0 sacks, 0 interceptions, 2 fumbles recovered | |
| LCB | Alontae Taylor | 26 | 2 | 15 | 4.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RCB | Kool-Aid McKinstry | 22 | Rook | 9 | ||
| SS | Will Harris | 29 | 5 | 13 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| FS | Tyrann Mathieu | 32 | 11 | 17 | 0.0 sacks, 3 interceptions, 1 fumble recovered |

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