| Offensive Starters | | | | | |
| QB | Tyler Shough | 26 | Rook | 9 | 221 for 327, 2,384 yards, 10 td, 6 int, & 45 rushes for 186 yards and 3 td | |
| RB | Alvin Kamara | 30 | 8 | 11 | 131 rushes for 471 yards, 1 td, & 33 catches for 186 yards and 0 td | |
| WR | Chris Olave | 25 | 3 | 16 | 100 catches for 1,163 yards, 9 td, & 1 rush for -3 yards and 0 td | |
| WR | Rashid Shaheed* | 27 | 3 | 9 | 44 catches for 499 yards, 2 td, & 2 rushes for 5 yards and 0 td | |
| TE | Juwan Johnson | 29 | 5 | 10 | 77 catches for 889 yards, 3 td | |
| TE | Foster Moreau | 28 | 6 | 9 | 7 catches for 59 yards, 0 td | |
| LT | Kelvin Banks | 21 | Rook | 17 | | |
| LG | Dillon Radunz | 27 | 4 | 10 | 1 fumble recovered | |
| C | Luke Fortner | 27 | 3 | 10 | 1 fumble recovered | |
| RG | Cesar Ruiz | 26 | 5 | 14 | 1 fumble recovered | |
| RT | Taliese Fuaga | 23 | 1 | 13 | | |
| Defensive Starters | | | | | |
| DE | Cameron Jordan | 36 | 14 | 17 | 10.5 sacks, 0 interceptions, 1 fumble recovered | |
| DE | Chase Young | 26 | 5 | 12 | 10.0 sacks, 0 interceptions, 3 fumbles recovered | |
| DT | Bryan Bresee | 24 | 2 | 15 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | |
| DT | Davon Godchaux | 31 | 8 | 14 | | |
| DT | Nathan Shepherd | 32 | 7 | 8 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LB | Demario Davis | 36 | 13 | 17 | 0.5 sacks, 0 interceptions, 1 fumble recovered | |
| LB | Pete Werner | 26 | 4 | 15 | 2.0 sacks, 0 interceptions, 3 fumbles recovered | |
| CB | Kool-Aid McKinstry | 23 | 1 | 17 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
| CB | Alontae Taylor | 27 | 3 | 16 | 2.0 sacks, 2 interceptions, 0 fumbles recovered | |
| S | Justin Reid | 28 | 7 | 15 | 0.5 sacks, 1 interception, 0 fumbles recovered | |
| S | Jonas Sanker | 23 | Rook | 16 | 0.0 sacks, 2 interceptions, 1 fumble recovered | |
Roster