| Offensive Starters | | | | | |
| QB | Eli Manning | 28 | 5 | 16 | 317 for 509, 4,021 yards, 27 td, 14 int, & 17 rushes for 65 yards and 0 td | |
| RB | Brandon Jacobs | 27 | 4 | 15 | 224 rushes for 835 yards, 5 td, & 18 catches for 184 yards and 1 td | |
| FB | Madison Hedgecock | 28 | 4 | 9 | 0 rushes for yards, 0 td, & 4 catches for 23 yards and 1 td | |
| WR | Mario Manningham | 23 | 1 | 10 | 57 catches for 822 yards, 5 td | |
| WR | Steve Smith* | 24 | 2 | 15 | 107 catches for 1,220 yards, 7 td | |
| TE | Kevin Boss | 25 | 2 | 15 | 42 catches for 567 yards, 5 td, & 1 rush for 16 yards and 0 td | |
| LT | David Diehl* | 29 | 6 | 16 | 1 fumble recovered | |
| LG | Rich Seubert | 30 | 8 | 14 | 1 fumble recovered | |
| C | Shaun O'Hara* | 32 | 9 | 16 | 1 fumble recovered | |
| RG | Chris Snee* | 27 | 5 | 16 | 1 fumble recovered | |
| RT | Kareem McKenzie | 30 | 8 | 12 | | |
| Defensive Starters | | | | | |
| LDE | Justin Tuck | 26 | 4 | 15 | 6.0 sacks, 0 interceptions, 1 fumble recovered | |
| LDT | Barry Cofield | 25 | 3 | 16 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDT | Fred Robbins | 32 | 9 | 12 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Osi Umenyiora | 28 | 6 | 11 | 7.0 sacks, 0 interceptions, 4 fumbles recovered | |
| LLB | Danny Clark | 32 | 9 | 11 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| MLB | Antonio Pierce | 31 | 8 | 9 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
| RLB | Michael Boley | 27 | 4 | 11 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Corey Webster | 27 | 4 | 13 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Terrell Thomas | 24 | 1 | 16 | 1.0 sacks, 5 interceptions, 0 fumbles recovered | |
| SS | Michael Johnson | 25 | 2 | 14 | 1.0 sacks, 1 interception, 1 fumble recovered | |
| FS | Aaron Rouse | 25 | 2 | 8 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
Roster