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- March 17, 2018: Traded 2018 1st round pick (6th overall, Quenton Nelson), 2018 2nd round pick (37th overall, Braden Smith), 2018 2nd round pick (49th overall subsequently traded, Dallas Goedert) and 2019 2nd round pick (34th overall, Rock Ya-Sin) to Colts for 2018 1st round pick (3rd overall, Sam Darnold)
- April 28, 2018: Traded 2018 5th round pick (157th overall, Tyler Conklin) to Vikings for 2018 5th round pick (167th overall subsequently traded, Daniel Carlson) and 2018 7th round pick (225th overall subsequently traded, Devante Downs)
- April 28, 2018: Traded 2018 7th round pick (235th overall, Zaire Franklin) to Colts for Henry Anderson
- April 28, 2018: Traded 2018 5th round pick (167th overall, Daniel Carlson) and 2018 7th round pick (225th overall, Devante Downs) to Vikings for 2018 6th round pick (180th overall, Folorunso Fatukasi) and 2018 6th round pick (204th overall, Trenton Cannon)
- May 22, 2018: Traded Christian Hackenberg to Raiders for a 2019 c round pick (terms not met; 7th round pick not conveyed)
- August 29, 2018: Traded Teddy Bridgewater and 2019 6th round pick (177th overall, Saquan Hampton) to Saints for 2019 3rd round pick (93rd overall subsequently traded, Miles Boykin)