| Offensive Starters | | | | | |
|---|
| QB | Jared Goff | 26 | 4 | 15 | 370 for 552, 3,952 yards, 20 td, 13 int, & 51 rushes for 99 yards and 4 td | |
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| RB | Darrell Henderson | 23 | 1 | 11 | 138 rushes for 624 yards, 5 td, & 16 catches for 159 yards and 1 td | |
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| WR | Cooper Kupp | 27 | 3 | 12 | 92 catches for 974 yards, 3 td, & 4 rushes for 33 yards and 0 td | |
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| WR | Josh Reynolds | 25 | 3 | 13 | 52 catches for 618 yards, 2 td, & 1 rush for 5 yards and 0 td | |
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| WR | Robert Woods | 28 | 7 | 16 | 90 catches for 936 yards, 6 td, & 24 rushes for 155 yards and 2 td | |
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| TE | Tyler Higbee | 27 | 4 | 15 | 44 catches for 521 yards, 5 td, & 1 rush for 1 yards and 0 td | |
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| LT | Andrew Whitworth | 39 | 14 | 9 | | |
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| LG | David Edwards | 23 | 1 | 14 | | |
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| C | Austin Blythe | 28 | 4 | 16 | | |
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| RG | Austin Corbett | 25 | 2 | 16 | 1 fumble recovered | |
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| RT | Rob Havenstein | 28 | 5 | 16 | 1 fumble recovered | |
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| Defensive Starters | | | | | |
|---|
| DE | Michael Brockers | 30 | 8 | 15 | | |
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| DT | Aaron Donald*+ | 29 | 6 | 16 | | |
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| NT | Sebastian Joseph | 25 | 2 | 16 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LOLB | Samson Ebukam | 25 | 3 | 14 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LILB | Troy Reeder | 26 | 1 | 7 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RILB | Kenny Young | 26 | 2 | 6 | 1.0 sacks, 1 interception, 1 fumble recovered | |
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| ROLB | Leonard Floyd | 28 | 4 | 16 | 10.5 sacks, 0 interceptions, 2 fumbles recovered | |
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| LCB | Troy Hill | 29 | 5 | 16 | 0.0 sacks, 3 interceptions, 2 fumbles recovered | |
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| RCB | Jalen Ramsey*+ | 26 | 4 | 15 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| SS | Jordan Fuller | 22 | Rook | 12 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| FS | John Johnson | 25 | 3 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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Roster