| Offensive Starters | | | | | |
|---|
| QB | Matthew Stafford | 33 | 12 | 17 | 404 for 601, 4,886 yards, 41 td, 17 int, & 32 rushes for 43 yards and 0 td | |
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| RB | Darrell Henderson | 24 | 2 | 10 | 149 rushes for 688 yards, 5 td, & 29 catches for 176 yards and 3 td | |
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| WR | Van Jefferson | 25 | 1 | 17 | 50 catches for 802 yards, 6 td, & 2 rushes for 20 yards and 0 td | |
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| WR | Cooper Kupp*+ | 28 | 4 | 17 | 145 catches for 1,947 yards, 16 td, & 4 rushes for 18 yards and 0 td | |
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| WR | Robert Woods | 29 | 8 | 9 | 45 catches for 556 yards, 4 td, & 8 rushes for 46 yards and 1 td | |
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| TE | Tyler Higbee | 28 | 5 | 15 | 61 catches for 560 yards, 5 td | |
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| LT | Andrew Whitworth | 40 | 15 | 15 | 1 fumble recovered | |
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| LG | David Edwards | 24 | 2 | 17 | | |
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| C | Brian Allen | 26 | 3 | 16 | | |
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| RG | Austin Corbett | 26 | 3 | 17 | | |
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| RT | Rob Havenstein | 29 | 6 | 15 | | |
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| Defensive Starters | | | | | |
|---|
| LDE | A'Shawn Robinson | 26 | 5 | 14 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LDT | Aaron Donald*+ | 30 | 7 | 17 | 12.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | Greg Gaines | 25 | 2 | 13 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDE | Von Miller | 32 | 10 | 8 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LLB | Troy Reeder | 27 | 2 | 10 | 2.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| MLB | Kenny Young | 27 | 3 | 7 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
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| RLB | Leonard Floyd | 29 | 5 | 17 | 9.5 sacks, 1 interception, 1 fumble recovered | |
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| LCB | Darious Williams | 28 | 3 | 13 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| RCB | Jalen Ramsey*+ | 27 | 5 | 16 | 0.0 sacks, 4 interceptions, 1 fumble recovered | |
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| SS | Jordan Fuller | 23 | 1 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| FS | Taylor Rapp | 24 | 2 | 17 | 1.5 sacks, 4 interceptions, 1 fumble recovered | |
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Roster