Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Matthew Stafford* | 35 | 14 | 15 | 326 for 521, 3,965 yards, 24 td, 11 int, & 21 rushes for 65 yards and 0 td | |
| RB | Kyren Williams* | 23 | 1 | 11 | 228 rushes for 1,144 yards, 12 td, & 32 catches for 206 yards and 3 td | |
| WR | Tutu Atwell | 24 | 2 | 14 | 39 catches for 483 yards, 3 td, & 5 rushes for 31 yards and 0 td | |
| WR | Cooper Kupp | 30 | 6 | 12 | 59 catches for 737 yards, 5 td, & 1 rush for -3 yards and 0 td | |
| WR | Puka Nacua* | 22 | Rook | 17 | 105 catches for 1,486 yards, 6 td, & 12 rushes for 89 yards and 0 td | |
| TE | Tyler Higbee | 30 | 7 | 15 | 47 catches for 495 yards, 2 td | |
| LT | Alaric Jackson | 25 | 2 | 15 | ||
| LG | Steve Avila | 24 | Rook | 17 | ||
| C | Coleman Shelton | 28 | 4 | 17 | ||
| RG | Kevin Dotson | 27 | 3 | 14 | ||
| RT | Rob Havenstein | 31 | 8 | 14 | ||
| Defensive Starters | ||||||
| LDE | Jonah Williams | 28 | 2 | 16 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| DT | Aaron Donald*+ | 32 | 9 | 16 | 8.0 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Bobby Brown | 23 | 2 | 13 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LOLB | Michael Hoecht | 26 | 2 | 17 | 6.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Ernest Jones | 24 | 2 | 15 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
| RILB | Troy Reeder | 29 | 4 | 6 | ||
| ROLB | Byron Young | 25 | Rook | 16 | 8.0 sacks, 0 interceptions, 1 fumble recovered | |
| LCB | Derion Kendrick | 23 | 1 | 12 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Ahkello Witherspoon | 28 | 6 | 17 | 0.0 sacks, 3 interceptions, 2 fumbles recovered | |
| SS | Jordan Fuller | 25 | 3 | 17 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
| FS | Russ Yeast | 24 | 1 | 9 |

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