Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Matthew Stafford | 36 | 15 | 16 | 340 for 517, 3,762 yards, 20 td, 8 int, & 30 rushes for 41 yards and 0 td | |
| RB | Kyren Williams | 24 | 2 | 16 | 316 rushes for 1,299 yards, 14 td, & 34 catches for 182 yards and 2 td | |
| WR | Cooper Kupp | 31 | 7 | 11 | 67 catches for 710 yards, 6 td, & 2 rushes for 10 yards and 0 td | |
| WR | Puka Nacua | 23 | 1 | 11 | 79 catches for 990 yards, 3 td, & 11 rushes for 46 yards and 1 td | |
| WR | Demarcus Robinson | 30 | 8 | 17 | 31 catches for 505 yards, 7 td | |
| TE | Colby Parkinson | 25 | 4 | 9 | 30 catches for 294 yards, 1 td | |
| LT | Alaric Jackson | 26 | 3 | 14 | ||
| LG | Steve Avila | 25 | 1 | 10 | 1 fumble recovered | |
| C | Beaux Limmer | 23 | Rook | 14 | 1 fumble recovered | |
| RG | Kevin Dotson | 28 | 4 | 16 | ||
| RT | Rob Havenstein | 32 | 9 | 11 | ||
| Defensive Starters | ||||||
| LDE | Kobie Turner | 25 | 1 | 16 | 8.0 sacks, 0 interceptions, 1 fumble recovered | |
| NT | Bobby Brown | 24 | 3 | 16 | ||
| RDE | Braden Fiske | 24 | Rook | 8 | 8.5 sacks, 0 interceptions, 2 fumbles recovered | |
| LOLB | Byron Young | 26 | 1 | 16 | 7.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Omar Speights | 23 | Rook | 10 | ||
| RLB | Christian Rozeboom | 27 | 3 | 11 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| ROLB | Jared Verse* | 24 | Rook | 16 | 4.5 sacks, 0 interceptions, 2 fumbles recovered | |
| LCB | Darious Williams | 31 | 6 | 11 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Cobie Durant | 26 | 2 | 14 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| SS | Quentin Lake | 25 | 2 | 16 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| FS | Kamren Curl | 25 | 4 | 16 | 1.0 sacks, 0 interceptions, 1 fumble recovered |

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