Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Justin Herbert | 26 | 4 | 17 | 332 for 504, 3,870 yards, 23 td, 3 int, & 69 rushes for 306 yards and 2 td | |
| RB | J.K. Dobbins | 26 | 4 | 11 | 195 rushes for 905 yards, 9 td, & 32 catches for 153 yards and 0 td | |
| FB | Scott Matlock | 24 | 1 | 11 | 0 rushes for yards, 0 td, & 4 catches for 28 yards and 0 td | |
| WR | Quentin Johnston | 23 | 1 | 11 | 55 catches for 711 yards, 8 td, & 3 rushes for 6 yards and 0 td | |
| WR | Ladd McConkey | 23 | Rook | 14 | 82 catches for 1,149 yards, 7 td | |
| TE | Will Dissly | 28 | 6 | 8 | 50 catches for 481 yards, 2 td | |
| LT | Rashawn Slater* | 25 | 3 | 15 | 1 fumble recovered | |
| LG | Zion Johnson | 25 | 2 | 17 | ||
| C | Bradley Bozeman | 30 | 6 | 17 | ||
| RG | Trey Pipkins | 28 | 5 | 15 | ||
| RT | Joe Alt | 21 | Rook | 16 | ||
| Defensive Starters | ||||||
| NT | Otito Ogbonnia | 24 | 2 | 17 | ||
| RDT | Poona Ford | 29 | 6 | 17 | 3.0 sacks, 1 interception, 0 fumbles recovered | |
| LOLB | Khalil Mack* | 33 | 10 | 16 | 6.0 sacks, 0 interceptions, 1 fumble recovered | |
| LILB | Daiyan Henley | 25 | 1 | 17 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| RILB | Denzel Perryman | 32 | 9 | 11 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| ROLB | Joey Bosa* | 29 | 8 | 9 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Kristian Fulton | 26 | 4 | 14 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Tarheeb Still | 22 | Rook | 12 | 0.5 sacks, 4 interceptions, 0 fumbles recovered | |
| SS | Derwin James* | 28 | 6 | 16 | 5.5 sacks, 1 interception, 1 fumble recovered | |
| FS | Alohi Gilman | 27 | 4 | 11 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| DB | Elijah Molden | 25 | 3 | 12 |
Roster