Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Justin Herbert* | 27 | 5 | 16 | 340 for 512, 3,727 yards, 26 td, 13 int, & 83 rushes for 498 yards and 2 td | |
| RB | Kimani Vidal | 24 | 1 | 10 | 155 rushes for 643 yards, 3 td, & 16 catches for 136 yards and 1 td | |
| FB | Scott Matlock | 25 | 2 | 8 | 0 rushes for yards, 0 td, & 4 catches for 12 yards and 1 td | |
| WR | Quentin Johnston | 24 | 2 | 10 | 51 catches for 735 yards, 8 td, & 2 rushes for 7 yards and 0 td | |
| WR | Ladd McConkey | 24 | 1 | 12 | 66 catches for 789 yards, 6 td | |
| TE | Oronde Gadsden II | 22 | Rook | 7 | 49 catches for 664 yards, 3 td | |
| LT | Joe Alt* | 22 | 1 | 6 | ||
| LG | Zion Johnson | 26 | 3 | 16 | ||
| C | Bradley Bozeman | 31 | 7 | 16 | ||
| RG | Mekhi Becton | 26 | 5 | 14 | ||
| RT | Trey Pipkins | 29 | 6 | 10 | ||
| Defensive Starters | ||||||
| DL | Da'Shawn Hand | 30 | 7 | 13 | ||
| DL | Teair Tart | 28 | 5 | 17 | ||
| LB | Daiyan Henley | 26 | 2 | 16 | 3.5 sacks, 2 interceptions, 0 fumbles recovered | |
| LB | Khalil Mack | 34 | 11 | 11 | 5.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LB | Denzel Perryman | 33 | 10 | 10 | ||
| LB | Tuli Tuipulotu* | 23 | 2 | 16 | 13.0 sacks, 0 interceptions, 1 fumble recovered | |
| CB | Donte Jackson | 30 | 7 | 15 | 0.0 sacks, 4 interceptions, 0 fumbles recovered | |
| CB | Elijah Molden | 26 | 4 | 12 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| CB | Tarheeb Still | 23 | 1 | 13 | ||
| S | Derwin James* | 29 | 7 | 16 | 2.0 sacks, 3 interceptions, 0 fumbles recovered | |
| S | Tony Jefferson | 33 | 12 | 8 | 0.0 sacks, 4 interceptions, 0 fumbles recovered |
Roster