| Offensive Starters | | | | | |
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| QB | Alex Smith | 21 | Rook | 7 | 84 for 165, 875 yards, 1 td, 11 int, & 30 rushes for 103 yards and 0 td | San Francisco 49ers / 1st / 1st pick / 2005 |
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| RB | Kevan Barlow | 26 | 4 | 12 | 176 rushes for 581 yards, 3 td, & 31 catches for 241 yards and 0 td | San Francisco 49ers / 3rd / 80th pick / 2001 |
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| FB | Fred Beasley | 31 | 7 | 7 | 0 rushes for yards, 0 td, & 2 catches for 12 yards and 0 td | San Francisco 49ers / 6th / 180th pick / 1998 |
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| WR | Brandon Lloyd | 24 | 2 | 15 | 48 catches for 733 yards, 5 td | San Francisco 49ers / 4th / 124th pick / 2003 |
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| WR | Johnnie Morton | 34 | 11 | 10 | 21 catches for 288 yards, 0 td | Detroit Lions / 1st / 21st pick / 1994 |
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| TE | Billy Bajema | 23 | Rook | 7 | 5 catches for 54 yards, 0 td | San Francisco 49ers / 7th / 249th pick / 2005 |
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| LT | Adam Snyder | 23 | Rook | 8 | 2 fumbles recovered | San Francisco 49ers / 3rd / 94th pick / 2005 |
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| LG | Justin Smiley | 24 | 1 | 16 | | San Francisco 49ers / 2nd / 46th pick / 2004 |
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| C | Jeremy Newberry | 29 | 6 | 10 | | San Francisco 49ers / 2nd / 58th pick / 1998 |
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| RG | Eric Heitmann | 25 | 3 | 16 | 2 fumbles recovered | San Francisco 49ers / 7th / 239th pick / 2002 |
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| RT | Kwame Harris | 23 | 2 | 16 | | San Francisco 49ers / 1st / 26th pick / 2003 |
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| Defensive Starters | | | | | |
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| LDE | Bryant Young | 33 | 11 | 13 | 8.0 sacks, 0 interceptions, 0 fumbles recovered | San Francisco 49ers / 1st / 7th pick / 1994 |
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| NT | Anthony Adams | 25 | 2 | 16 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | San Francisco 49ers / 2nd / 57th pick / 2003 |
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| RDE | Marques Douglas | 28 | 5 | 15 | 1.0 sacks, 0 interceptions, 2 fumbles recovered | |
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| LOLB | Julian Peterson | 27 | 5 | 14 | 3.0 sacks, 0 interceptions, 1 fumble recovered | San Francisco 49ers / 1st / 16th pick / 2000 |
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| LILB | Brandon Moore | 26 | 3 | 10 | 5.0 sacks, 1 interception, 1 fumble recovered | |
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| RILB | Derek Smith | 30 | 8 | 16 | 0.0 sacks, 1 interception, 1 fumble recovered | Washington Redskins / 3rd / 80th pick / 1997 |
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| ROLB | Andre Carter | 26 | 4 | 14 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | San Francisco 49ers / 1st / 7th pick / 2001 |
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| LCB | Bruce Thornton | 25 | 1 | 11 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | Dallas Cowboys / 4th / 121st pick / 2004 |
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| RCB | Shawntae Spencer | 23 | 1 | 14 | 0.0 sacks, 4 interceptions, 0 fumbles recovered | San Francisco 49ers / 2nd / 58th pick / 2004 |
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| SS | Tony Parrish | 30 | 7 | 9 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | Chicago Bears / 2nd / 35th pick / 1998 |
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| FS | Mike Adams | 24 | 1 | 10 | 1.0 sacks, 4 interceptions, 1 fumble recovered | |
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