| Offensive Starters | | | | | |
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| QB | Colin Kaepernick | 26 | 2 | 16 | 243 for 416, 3,197 yards, 21 td, 8 int, & 92 rushes for 524 yards and 4 td | |
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| RB | Frank Gore* | 30 | 8 | 16 | 276 rushes for 1,128 yards, 9 td, & 16 catches for 141 yards and 0 td | |
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| RB | Bruce Miller | 26 | 2 | 13 | 7 rushes for 13 yards, 0 td, & 25 catches for 243 yards and 0 td | |
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| WR | Anquan Boldin | 33 | 10 | 16 | 85 catches for 1,179 yards, 7 td, & 2 rushes for 11 yards and 0 td | |
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| WR | Michael Crabtree | 26 | 4 | 5 | 19 catches for 284 yards, 1 td | |
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| TE | Vernon Davis* | 29 | 7 | 15 | 52 catches for 850 yards, 13 td | |
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| LT | Joe Staley* | 29 | 6 | 16 | | |
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| LG | Mike Iupati* | 26 | 3 | 12 | | |
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| C | Jonathan Goodwin | 35 | 11 | 16 | | |
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| RG | Alex Boone | 26 | 3 | 16 | | |
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| RT | Anthony Davis | 24 | 3 | 16 | | |
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| Defensive Starters | | | | | |
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| LDE | Ray McDonald | 29 | 6 | 14 | 3.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| NT | Glenn Dorsey | 28 | 5 | 13 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDE | Justin Smith* | 34 | 12 | 16 | 6.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LOLB | Ahmad Brooks* | 29 | 7 | 16 | 8.5 sacks, 1 interception, 1 fumble recovered | |
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| LILB | NaVorro Bowman*+ | 25 | 3 | 16 | 5.0 sacks, 2 interceptions, 2 fumbles recovered | |
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| RILB | Patrick Willis* | 28 | 6 | 14 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| ROLB | Aldon Smith | 24 | 2 | 8 | 8.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LCB | Carlos Rogers | 32 | 8 | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| RCB | Tarell Brown | 28 | 6 | 10 | 0.0 sacks, 0 interceptions, 2 fumbles recovered | |
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| SS | Donte Whitner | 28 | 7 | 16 | 0.0 sacks, 2 interceptions, 1 fumble recovered | |
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| FS | Eric Reid* | 22 | Rook | 16 | 0.0 sacks, 4 interceptions, 2 fumbles recovered | |
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Roster