| Offensive Starters | | | | | |
|---|
| QB | Jimmy Garoppolo | 28 | 5 | 16 | 329 for 476, 3,978 yards, 27 td, 13 int, & 46 rushes for 62 yards and 1 td | |
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| RB | Tevin Coleman | 26 | 4 | 11 | 137 rushes for 544 yards, 6 td, & 21 catches for 180 yards and 1 td | |
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| FB | Kyle Juszczyk* | 28 | 6 | 12 | 3 rushes for 7 yards, 0 td, & 20 catches for 239 yards and 1 td | |
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| WR | Deebo Samuel | 23 | Rook | 11 | 57 catches for 802 yards, 3 td, & 14 rushes for 159 yards and 3 td | |
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| WR | Emmanuel Sanders | 32 | 9 | 9 | 36 catches for 502 yards, 3 td | |
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| TE | George Kittle*+ | 26 | 2 | 14 | 85 catches for 1,053 yards, 5 td, & 5 rushes for 22 yards and 0 td | |
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| LT | Justin Skule | 23 | Rook | 8 | | |
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| LG | Laken Tomlinson | 27 | 4 | 16 | | |
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| C | Weston Richburg | 28 | 5 | 13 | | |
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| RG | Michael Person | 31 | 6 | 14 | | |
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| RT | Mike McGlinchey | 25 | 1 | 12 | | |
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| Defensive Starters | | | | | |
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| LDE | Nick Bosa* | 22 | Rook | 14 | 9.0 sacks, 1 interception, 2 fumbles recovered | |
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| LDT | D.J. Jones | 24 | 2 | 11 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | DeForest Buckner | 25 | 3 | 16 | 7.5 sacks, 0 interceptions, 4 fumbles recovered | |
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| RDE | Arik Armstead | 26 | 4 | 16 | 10.0 sacks, 0 interceptions, 1 fumble recovered | |
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| LLB | Kwon Alexander | 25 | 4 | 8 | 0.5 sacks, 1 interception, 0 fumbles recovered | |
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| MLB | Fred Warner | 23 | 1 | 16 | 3.0 sacks, 1 interception, 0 fumbles recovered | |
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| RLB | Dre Greenlaw | 22 | Rook | 11 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| LCB | Richard Sherman* | 31 | 8 | 15 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| RCB | Emmanuel Moseley | 23 | 1 | 9 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| SS | Jaquiski Tartt | 27 | 4 | 12 | 0.5 sacks, 0 interceptions, 2 fumbles recovered | |
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| FS | Jimmie Ward | 28 | 5 | 13 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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Roster