Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Nick Mullens | 25 | 2 | 8 | 211 for 326, 2,437 yards, 12 td, 12 int, & 9 rushes for 8 yards and 0 td | |
| RB | Raheem Mostert | 28 | 5 | 8 | 104 rushes for 521 yards, 2 td, & 16 catches for 156 yards and 1 td | |
| FB | Kyle Juszczyk* | 29 | 7 | 15 | 17 rushes for 64 yards, 2 td, & 19 catches for 202 yards and 4 td | |
| WR | Brandon Aiyuk | 22 | Rook | 11 | 60 catches for 748 yards, 5 td, & 6 rushes for 77 yards and 2 td | |
| WR | Richie James | 25 | 2 | 7 | 23 catches for 394 yards, 1 td | |
| TE | George Kittle | 27 | 3 | 8 | 48 catches for 634 yards, 2 td, & 2 rushes for 17 yards and 0 td | |
| LT | Trent Williams* | 32 | 10 | 14 | ||
| LG | Laken Tomlinson | 28 | 5 | 16 | ||
| C | Ben Garland | 32 | 6 | 5 | ||
| RG | Daniel Brunskill | 26 | 1 | 16 | ||
| RT | Mike McGlinchey | 26 | 2 | 16 | ||
| Defensive Starters | ||||||
| LDE | Arik Armstead | 27 | 5 | 16 | 3.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Javon Kinlaw | 23 | Rook | 12 | 1.5 sacks, 1 interception, 0 fumbles recovered | |
| RDT | D.J. Jones | 25 | 3 | 14 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Kerry Hyder | 29 | 5 | 14 | 8.5 sacks, 0 interceptions, 1 fumble recovered | |
| LLB | Azeez Al-Shaair | 23 | 1 | 5 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| MLB | Fred Warner*+ | 24 | 2 | 16 | 1.0 sacks, 2 interceptions, 2 fumbles recovered | |
| RLB | Dre Greenlaw | 23 | 1 | 11 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Jason Verrett | 29 | 6 | 13 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RCB | Emmanuel Moseley | 24 | 2 | 8 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| SS | Tarvarius Moore | 24 | 2 | 8 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| FS | Jimmie Ward | 29 | 6 | 14 |
Roster