| Offensive Starters | | | | | |
|---|
| QB | Nick Mullens | 25 | 2 | 8 | 211 for 326, 2,437 yards, 12 td, 12 int, & 9 rushes for 8 yards and 0 td | |
|---|
| RB | Raheem Mostert | 28 | 5 | 8 | 104 rushes for 521 yards, 2 td, & 16 catches for 156 yards and 1 td | |
|---|
| FB | Kyle Juszczyk* | 29 | 7 | 15 | 17 rushes for 64 yards, 2 td, & 19 catches for 202 yards and 4 td | |
|---|
| WR | Brandon Aiyuk | 22 | Rook | 11 | 60 catches for 748 yards, 5 td, & 6 rushes for 77 yards and 2 td | |
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| WR | Richie James | 25 | 2 | 7 | 23 catches for 394 yards, 1 td | |
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| TE | George Kittle | 27 | 3 | 8 | 48 catches for 634 yards, 2 td, & 2 rushes for 17 yards and 0 td | |
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| LT | Trent Williams* | 32 | 10 | 14 | | |
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| LG | Laken Tomlinson | 28 | 5 | 16 | | |
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| C | Ben Garland | 32 | 6 | 5 | | |
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| RG | Daniel Brunskill | 26 | 1 | 16 | | |
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| RT | Mike McGlinchey | 26 | 2 | 16 | | |
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| Defensive Starters | | | | | |
|---|
| LDE | Arik Armstead | 27 | 5 | 16 | 3.5 sacks, 0 interceptions, 0 fumbles recovered | |
|---|
| LDT | Javon Kinlaw | 23 | Rook | 12 | 1.5 sacks, 1 interception, 0 fumbles recovered | |
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| RDT | D.J. Jones | 25 | 3 | 14 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDE | Kerry Hyder | 29 | 5 | 14 | 8.5 sacks, 0 interceptions, 1 fumble recovered | |
|---|
| LLB | Azeez Al-Shaair | 23 | 1 | 5 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
|---|
| MLB | Fred Warner*+ | 24 | 2 | 16 | 1.0 sacks, 2 interceptions, 2 fumbles recovered | |
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| RLB | Dre Greenlaw | 23 | 1 | 11 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LCB | Jason Verrett | 29 | 6 | 13 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| RCB | Emmanuel Moseley | 24 | 2 | 8 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| SS | Tarvarius Moore | 24 | 2 | 8 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| FS | Jimmie Ward | 29 | 6 | 14 | | |
|---|
Roster