| Offensive Starters | | | | | |
|---|
| QB | Jimmy Garoppolo | 30 | 7 | 15 | 301 for 441, 3,810 yards, 20 td, 12 int, & 38 rushes for 51 yards and 3 td | |
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| RB | Elijah Mitchell | 23 | Rook | 10 | 207 rushes for 963 yards, 5 td, & 19 catches for 137 yards and 1 td | |
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| FB | Kyle Juszczyk* | 30 | 8 | 16 | 8 rushes for 22 yards, 1 td, & 30 catches for 296 yards and 1 td | |
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| WR | Brandon Aiyuk | 23 | 1 | 16 | 56 catches for 826 yards, 5 td, & 5 rushes for 17 yards and 0 td | |
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| WR | Deebo Samuel*+ | 25 | 2 | 15 | 77 catches for 1,405 yards, 6 td, & 59 rushes for 365 yards and 8 td | |
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| TE | George Kittle* | 28 | 4 | 14 | 71 catches for 910 yards, 6 td, & 3 rushes for 20 yards and 0 td | |
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| LT | Trent Williams*+ | 33 | 11 | 15 | | |
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| LG | Laken Tomlinson* | 29 | 6 | 17 | | |
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| C | Alex Mack* | 36 | 12 | 17 | 1 fumble recovered | |
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| RG | Daniel Brunskill | 27 | 2 | 17 | | |
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| RT | Mike McGlinchey | 26 | 3 | 8 | | |
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| Defensive Starters | | | | | |
|---|
| LDE | Samson Ebukam | 26 | 4 | 11 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LDT | Arik Armstead | 28 | 6 | 17 | 6.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | D.J. Jones | 26 | 4 | 17 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDE | Nick Bosa* | 24 | 2 | 17 | 15.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LLB | Azeez Al-Shaair | 24 | 2 | 13 | 2.0 sacks, 1 interception, 2 fumbles recovered | |
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| MLB | Fred Warner | 25 | 3 | 16 | 0.5 sacks, 0 interceptions, 3 fumbles recovered | |
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| RLB | Marcell Harris | 27 | 3 | 7 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| LCB | Emmanuel Moseley | 25 | 3 | 11 | 0.0 sacks, 1 interception, 1 fumble recovered | |
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| RCB | Josh Norman | 34 | 9 | 14 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| SS | Jaquiski Tartt | 29 | 6 | 14 | | |
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| FS | Jimmie Ward | 30 | 7 | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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Roster