Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Jimmy Garoppolo | 31 | 8 | 10 | 207 for 308, 2,437 yards, 16 td, 4 int, & 23 rushes for 33 yards and 2 td | |
| RB | Christian McCaffrey* | 26 | 5 | 10 | 159 rushes for 746 yards, 6 td, & 52 catches for 464 yards and 4 td | |
| FB | Kyle Juszczyk* | 31 | 9 | 12 | 7 rushes for 26 yards, 1 td, & 19 catches for 200 yards and 1 td | |
| WR | Brandon Aiyuk | 24 | 2 | 17 | 78 catches for 1,015 yards, 8 td, & 2 rushes for 23 yards and 0 td | |
| WR | Deebo Samuel | 26 | 3 | 12 | 56 catches for 632 yards, 2 td, & 42 rushes for 232 yards and 3 td | |
| TE | George Kittle* | 29 | 5 | 15 | 60 catches for 765 yards, 11 td | |
| LT | Trent Williams*+ | 34 | 12 | 14 | ||
| LG | Aaron Banks | 25 | 1 | 16 | ||
| C | Jake Brendel | 30 | 6 | 17 | ||
| RG | Spencer Burford | 22 | Rook | 16 | ||
| RT | Mike McGlinchey | 28 | 4 | 17 | ||
| Defensive Starters | ||||||
| LDE | Samson Ebukam | 27 | 5 | 15 | 5.0 sacks, 0 interceptions, 1 fumble recovered | |
| LDT | Kevin Givens | 25 | 3 | 11 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDT | Arik Armstead | 29 | 7 | 9 | ||
| RDE | Nick Bosa*+ | 25 | 3 | 16 | 18.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LLB | Azeez Al-Shaair | 25 | 3 | 9 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| MLB | Fred Warner*+ | 26 | 4 | 17 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| RLB | Dre Greenlaw | 25 | 3 | 15 | 0.0 sacks, 1 interception, 2 fumbles recovered | |
| LCB | Deommodore Lenoir | 23 | 1 | 13 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Charvarius Ward | 26 | 4 | 17 | 0.0 sacks, 1 interception, 1 fumble recovered | |
| SS | Talanoa Hufanga*+ | 23 | 1 | 17 | 2.0 sacks, 4 interceptions, 0 fumbles recovered | |
| FS | Tashaun Gipson | 32 | 10 | 17 | 0.5 sacks, 5 interceptions, 0 fumbles recovered |
Roster