Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Brock Purdy | 25 | 2 | 15 | 300 for 455, 3,864 yards, 20 td, 12 int, & 66 rushes for 323 yards and 5 td | |
| RB | Jordan Mason | 25 | 2 | 6 | 153 rushes for 789 yards, 3 td, & 11 catches for 91 yards and 0 td | |
| FB | Kyle Juszczyk* | 33 | 11 | 15 | 5 rushes for 26 yards, 1 td, & 19 catches for 200 yards and 2 td | |
| WR | Jauan Jennings | 27 | 3 | 10 | 77 catches for 975 yards, 6 td | |
| WR | Deebo Samuel | 28 | 5 | 15 | 51 catches for 670 yards, 3 td, & 42 rushes for 136 yards and 1 td | |
| TE | George Kittle* | 31 | 7 | 15 | 78 catches for 1,106 yards, 8 td | |
| LT | Trent Williams | 36 | 14 | 10 | ||
| LG | Aaron Banks | 27 | 3 | 13 | 1 fumble recovered | |
| C | Jake Brendel | 32 | 8 | 17 | ||
| RG | Dominick Puni | 24 | Rook | 17 | ||
| RT | Colton McKivitz | 28 | 4 | 17 | ||
| Defensive Starters | ||||||
| LDE | Nick Bosa* | 27 | 5 | 14 | 9.0 sacks, 1 interception, 1 fumble recovered | |
| LDT | Maliek Collins | 29 | 8 | 17 | 5.0 sacks, 0 interceptions, 2 fumbles recovered | |
| RDT | Jordan Elliott | 27 | 4 | 13 | ||
| RDE | Leonard Floyd | 32 | 8 | 17 | 8.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LLB | De'Vondre Campbell | 31 | 8 | 12 | ||
| MLB | Fred Warner*+ | 28 | 6 | 17 | 1.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RLB | Deommodore Lenoir | 25 | 3 | 15 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RLB | Dee Winters | 24 | 1 | 10 | ||
| LCB | Charvarius Ward | 28 | 6 | 12 | ||
| SS | Malik Mustapha | 22 | Rook | 12 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| FS | Ji'Ayir Brown | 24 | 1 | 13 | 0.0 sacks, 1 interception, 0 fumbles recovered |
Roster