Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Brock Purdy | 26 | 3 | 9 | 197 for 284, 2,167 yards, 20 td, 10 int, & 33 rushes for 147 yards and 3 td | |
| RB | Christian McCaffrey*+ | 29 | 8 | 17 | 311 rushes for 1,202 yards, 10 td, & 102 catches for 924 yards and 7 td | |
| FB | Kyle Juszczyk*+ | 34 | 12 | 17 | 2 rushes for -3 yards, 0 td, & 24 catches for 213 yards and 2 td | |
| WR | Jauan Jennings | 28 | 4 | 15 | 55 catches for 643 yards, 9 td | |
| WR | Ricky Pearsall | 25 | 1 | 9 | 36 catches for 528 yards, 0 td, & 2 rushes for -2 yards and 0 td | |
| TE | George Kittle* | 32 | 8 | 11 | 57 catches for 628 yards, 7 td, & 1 rush for -3 yards and 0 td | |
| LT | Trent Williams* | 37 | 15 | 16 | ||
| LG | Spencer Burford | 25 | 3 | 9 | ||
| C | Jake Brendel | 33 | 9 | 15 | ||
| RG | Dominick Puni | 25 | 1 | 17 | ||
| RT | Colton McKivitz | 29 | 5 | 17 | 1 fumble recovered | |
| Defensive Starters | ||||||
| DL | Kalia Davis | 27 | 2 | 17 | ||
| DL | Jordan Elliott | 28 | 5 | 16 | ||
| DL | Sam Okuayinonu | 27 | 3 | 12 | ||
| DL | Mykel Williams | 21 | Rook | 9 | ||
| LB | Tatum Bethune | 24 | 1 | 8 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LB | Luke Gifford* | 30 | 6 | 9 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| LB | Dee Winters | 25 | 2 | 17 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| CB | Renardo Green | 25 | 1 | 14 | ||
| CB | Deommodore Lenoir | 26 | 4 | 17 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| S | Ji'Ayir Brown | 25 | 2 | 13 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| S | Malik Mustapha | 23 | 1 | 10 | 0.0 sacks, 1 interception, 0 fumbles recovered |

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