| Offensive Starters | | | | | |
|---|
| QB | Taylor Heinicke | 28 | 4 | 15 | 321 for 494, 3,419 yards, 20 td, 15 int, & 60 rushes for 313 yards and 1 td | |
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| RB | Antonio Gibson | 23 | 1 | 14 | 258 rushes for 1,037 yards, 7 td, & 42 catches for 294 yards and 3 td | |
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| WR | Dyami Brown | 22 | Rook | 6 | 12 catches for 165 yards, 0 td, & 1 rush for -4 yards and 0 td | |
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| WR | Adam Humphries | 28 | 6 | 11 | 41 catches for 383 yards, 0 td | |
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| WR | Terry McLaurin | 26 | 2 | 17 | 77 catches for 1,053 yards, 5 td, & 1 rush for 12 yards and 0 td | |
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| TE | John Bates | 24 | Rook | 8 | 20 catches for 249 yards, 1 td | |
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| LT | Charles Leno Jr. | 30 | 7 | 17 | 1 fumble recovered | |
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| LG | Ereck Flowers | 27 | 6 | 16 | | |
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| C | Chase Roullier | 28 | 4 | 8 | 1 fumble recovered | |
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| RG | Brandon Scherff* | 30 | 6 | 11 | | |
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| RT | Samuel Cosmi | 22 | Rook | 9 | 1 fumble recovered | |
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| Defensive Starters | | | | | |
|---|
| LDE | Chase Young | 22 | 1 | 9 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LDT | Jonathan Allen* | 26 | 4 | 17 | 9.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | Daron Payne | 24 | 3 | 17 | 4.5 sacks, 0 interceptions, 1 fumble recovered | |
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| RDE | Montez Sweat | 25 | 2 | 10 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LLB | Cole Holcomb | 25 | 2 | 16 | 1.0 sacks, 2 interceptions, 1 fumble recovered | |
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| MLB | Jamin Davis | 23 | Rook | 8 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RLB | Jonathan Bostic | 30 | 8 | 4 | | |
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| LCB | Kendall Fuller | 26 | 5 | 16 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| RCB | William Jackson III | 29 | 4 | 12 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| SS | Landon Collins | 27 | 6 | 13 | 3.0 sacks, 2 interceptions, 2 fumbles recovered | |
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| FS | Kamren Curl | 22 | 1 | 14 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
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Roster