| QB | Peyton Manning | IND | 33 | 11 | 16 | 16 | 393 | 571 | 4500 | 33 | 16 | 19 | -13 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 2nd Tm, SN: 2nd Tm |
| QB | Drew Brees | NOR | 30 | 8 | 15 | 15 | 363 | 514 | 4388 | 34 | 11 | 22 | 33 | 2 | 1 | -4 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm, SN: 1st Tm |
| QB | Philip Rivers | SDG | 28 | 5 | 16 | 16 | 317 | 486 | 4254 | 28 | 9 | 26 | 50 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 | PFF: 1st Tm |
| RB | Chris Johnson | TEN | 24 | 1 | 16 | 16 | 0 | 1 | 0 | 0 | 0 | 358 | 2006 | 14 | 50 | 503 | 2 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| RB | Adrian Peterson | MIN | 24 | 2 | 16 | 15 | 0 | 0 | 0 | 0 | 0 | 314 | 1383 | 18 | 43 | 436 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, SN: 1st Tm |
| RB | Steven Jackson | STL | 26 | 5 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 324 | 1416 | 4 | 51 | 322 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm, SN: 2nd Tm |
| RB | Maurice Jones-Drew | JAX | 24 | 3 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 312 | 1391 | 15 | 53 | 374 | 1 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., PFF: 2nd Tm, SN: 2nd Tm |
| RB | Ray Rice | BAL | 22 | 1 | 16 | 15 | 0 | 1 | 0 | 0 | 0 | 254 | 1339 | 7 | 78 | 702 | 1 | 0 | 0.0 | 0 | AP: 2nd Tm |
| FB | Leonard Weaver | PHI | 27 | 4 | 16 | 8 | 0 | 0 | 0 | 0 | 0 | 70 | 323 | 2 | 15 | 140 | 2 | 3 | 0.0 | 0 | AP: 1st Tm |
| FB | Lousaka Polite | MIA | 28 | 5 | 16 | 9 | 0 | 0 | 0 | 0 | 0 | 37 | 123 | 0 | 11 | 51 | 0 | 0 | 0.0 | 0 | PFF: 1st Tm |
| FB | Le'Ron McClain | BAL | 25 | 2 | 16 | 14 | 0 | 0 | 0 | 0 | 0 | 46 | 180 | 2 | 21 | 141 | 0 | 0 | 0.0 | 0 | AP: 2nd Tm, PFF: 2nd Tm |
| WR | Andre Johnson | HOU | 28 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 10 | 0 | 101 | 1569 | 9 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 2nd Tm, SN: 1st Tm |
| WR | Wes Welker | NWE | 28 | 5 | 14 | 13 | 0 | 0 | 0 | 0 | 0 | 5 | 36 | 0 | 123 | 1348 | 4 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm |
| WR | Larry Fitzgerald | ARI | 26 | 5 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 97 | 1092 | 13 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm, SN: 1st Tm |
| WR | Reggie Wayne | IND | 31 | 8 | 16 | 16 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 100 | 1264 | 10 | 0 | 0.0 | 0 | AP: 2nd Tm, PFF: 1st Tm, SN: 2nd Tm |
| WR | Vincent Jackson | SDG | 26 | 4 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 3 | 11 | 0 | 68 | 1167 | 9 | 0 | 0.0 | 0 | PFF: 1st Tm |
| WR | Sidney Rice | MIN | 23 | 2 | 16 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 83 | 1312 | 8 | 0 | 0.0 | 0 | PFF: 2nd Tm |
| TE | Dallas Clark | IND | 30 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 11 | 0 | 100 | 1106 | 10 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 2nd Tm, SN: 1st Tm |
| TE | Jason Witten | DAL | 27 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 94 | 1030 | 2 | 0 | 0.0 | 0 | PFF: 1st Tm, SN: 2nd Tm |
| TE | Vernon Davis | SFO | 25 | 3 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 78 | 965 | 13 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf. |
| TE | Antonio Gates | SDG | 29 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 79 | 1157 | 8 | 0 | 0.0 | 0 | AP: 2nd Tm |
| T | Joe Thomas | CLE | 25 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 2nd Tm |
| T | Ryan Clady | DEN | 23 | 1 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, SN: 1st Tm |
| T | Jake Long | MIA | 24 | 1 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.0 | 0 | AP: 2nd Tm, PFF: 2nd Tm, SN: 1st Tm |
| T | Jason Peters | PHI | 27 | 5 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf. |
| T | Jon Stinchcomb | NOR | 30 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.0 | 0 | FW: 1st Tm All-Conf. |
| T | Michael Roos | TEN | 27 | 4 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | AP: 2nd Tm, SN: 2nd Tm |
| LG | Carl Nicks | NOR | 24 | 1 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.0 | 0 | PFF: 1st Tm |
| G | Jahri Evans | NOR | 26 | 3 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| G | Steve Hutchinson | MIN | 32 | 8 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, SN: 1st Tm |
| G | Logan Mankins | NWE | 27 | 4 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm, PFF: 2nd Tm, SN: 2nd Tm |
| G | Alan Faneca | NYJ | 33 | 11 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf. |
| G | Kris Dielman | SDG | 28 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | AP: 2nd Tm |
| C | Nick Mangold | NYJ | 25 | 3 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| C | Andre Gurode | DAL | 31 | 7 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm |
| C | Ryan Kalil | CAR | 24 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.0 | 0 | PFF: 2nd Tm |
| RG | Steve Neal | NWE | 33 | 7 | 12 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.0 | 0 | PFF: 2nd Tm |
| RT | Damien Woody | NYJ | 32 | 10 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | PFF: 1st Tm |
| RT | David Stewart | TEN | 27 | 3 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | PFF: 2nd Tm |
| DE | Dwight Freeney | IND | 29 | 7 | 14 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 19 | 13.5 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| DE | Jared Allen | MIN | 27 | 5 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 43 | 14.5 | 1 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, SN: 1st Tm |
| DE | Justin Smith | SFO | 30 | 8 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 41 | 6.0 | 0 | PFF: 1st Tm |
| DE | Trent Cole | PHI | 27 | 4 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 48 | 12.5 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm, PFF: 2nd Tm, SN: 2nd Tm |
| DE | Mario Williams | HOU | 24 | 3 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 38 | 9.0 | 0 | FW: 1st Tm All-Conf. |
| DE | Julius Peppers | CAR | 29 | 7 | 16 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 36 | 10.5 | 2 | AP: 2nd Tm, SN: 2nd Tm |
| DE | Robert Mathis | IND | 28 | 6 | 14 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 9.5 | 0 | PFF: 2nd Tm |
| DT | Kevin Williams | MIN | 29 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 6.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| DT | Haloti Ngata | BAL | 25 | 3 | 14 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 26 | 1.5 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm, FW: 1st Tm, SN: 2nd Tm |
| DT | Jay Ratliff | DAL | 28 | 4 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 29 | 6.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm |
| DT | Darnell Dockett | ARI | 28 | 5 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 42 | 7.0 | 1 | SN: 1st Tm, AP: 2nd Tm |
| DT | Jonathan Babineaux | ATL | 28 | 4 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 37 | 6.0 | 0 | PFF: 1st Tm |
| DT | Vince Wilfork | NWE | 28 | 5 | 13 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 31 | 0.0 | 0 | FW: 1st Tm All-Conf., SN: 2nd Tm |
| DT | Kelly Gregg | BAL | 33 | 10 | 16 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 46 | 3.0 | 0 | PFF: 2nd Tm |
| DT | Albert Haynesworth | WAS | 28 | 7 | 12 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 29 | 4.0 | 0 | PFF: 2nd Tm |
| OLB | DeMarcus Ware | DAL | 27 | 4 | 16 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 45 | 11.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| OLB | Elvis Dumervil | DEN | 25 | 3 | 16 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 42 | 17.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, SN: 1st Tm |
| OLB | LaMarr Woodley | PIT | 25 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 51 | 13.5 | 0 | PFF: 1st Tm, AP: 2nd Tm |
| OLB | Lance Briggs | CHI | 29 | 6 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 93 | 2.5 | 1 | FW: 1st Tm All-Conf., AP: 2nd Tm |
| OLB | Brian Cushing | HOU | 22 | Rook | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 86 | 4.0 | 4 | FW: 1st Tm All-Conf., SN: 2nd Tm |
| OLB | James Harrison | PIT | 31 | 7 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 60 | 10.0 | 0 | AP: 2nd Tm, SN: 2nd Tm |
| OLB | Anthony Spencer | DAL | 25 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 50 | 6.0 | 1 | PFF: 2nd Tm |
| OLB | Daryl Smith | JAX | 27 | 5 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 84 | 1.5 | 1 | PFF: 2nd Tm |
| ILB | Jon Beason | CAR | 24 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 111 | 3.0 | 3 | AP: 2nd Tm, SN: 2nd Tm |
| ILB | David Harris | NYJ | 25 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 82 | 5.5 | 2 | AP: 2nd Tm |
| MLB | Patrick Willis | SFO | 24 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 114 | 4.0 | 3 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| MLB | Ray Lewis | BAL | 34 | 13 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 95 | 3.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, PFF: 2nd Tm |
| CB | Darrelle Revis | NYJ | 24 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 47 | 0.0 | 6 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| CB | Charles Woodson | GNB | 33 | 11 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 66 | 2.0 | 9 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| CB | Asante Samuel | PHI | 28 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 39 | 0.0 | 9 | FW: 1st Tm All-Conf., AP: 2nd Tm, SN: 2nd Tm |
| CB | Nnamdi Asomugha | OAK | 28 | 6 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 30 | 0.0 | 1 | FW: 1st Tm All-Conf., AP: 2nd Tm, SN: 2nd Tm |
| CB | Leon Hall | CIN | 25 | 2 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 58 | 0.0 | 6 | AP: 2nd Tm, PFF: 2nd Tm |
| CB | Dominique Rodgers-Cromartie | ARI | 23 | 1 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 48 | 0.0 | 6 | PFF: 2nd Tm |
| SS | George Wilson | BUF | 28 | 4 | 16 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 70 | 2.0 | 4 | PFF: 1st Tm |
| SS | Reed Doughty | WAS | 27 | 3 | 15 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 75 | 2.0 | 1 | PFF: 2nd Tm |
| S | Darren Sharper | NOR | 34 | 12 | 14 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 51 | 0.5 | 9 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, SN: 1st Tm |
| S | Adrian Wilson | ARI | 30 | 8 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 62 | 2.0 | 5 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm |
| S | Brian Dawkins | DEN | 36 | 13 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 95 | 0.0 | 2 | FW: 1st Tm All-Conf., AP: 2nd Tm, SN: 1st Tm |
| S | Ed Reed | BAL | 31 | 7 | 12 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 42 | 0.0 | 3 | AP: 2nd Tm, PFF: 1st Tm, SN: 2nd Tm |
| S | Jairus Byrd | BUF | 23 | Rook | 14 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 33 | 0.0 | 9 | FW: 1st Tm All-Conf., SN: 2nd Tm |
| S | Nick Collins | GNB | 26 | 4 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 44 | 1.0 | 6 | AP: 2nd Tm, PFF: 2nd Tm |
| K | Sebastian Janikowski | OAK | 31 | 9 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.0 | 0 | PFF: 1st Tm |
| K | Rob Bironas | TEN | 31 | 4 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.0 | 0 | PFF: 2nd Tm |
| P | Shane Lechler | OAK | 33 | 9 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 1st Tm |
| P | Andy Lee | SFO | 27 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm |
| P | Donnie Jones | STL | 29 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.0 | 0 | AP: 2nd Tm, SN: 2nd Tm |
| P | Ben Graham | ARI | 36 | 4 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.0 | 0 | PFF: 2nd Tm |
| PR | DeSean Jackson | PHI | 23 | 1 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 11 | 137 | 1 | 62 | 1156 | 9 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., FW: 1st Tm All-Conf., AP: 2nd Tm, FW: 1st Tm, SN: 1st Tm |
| KR | Josh Cribbs | CLE | 26 | 4 | 16 | 12 | 1 | 4 | 18 | 0 | 1 | 55 | 381 | 1 | 20 | 135 | 1 | 8 | 0.0 | 0 | FW: 1st Tm All-Conf., FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, PFF: 1st Tm, SN: 2nd Tm |
| KR | Percy Harvin | MIN | 21 | Rook | 15 | 8 | 0 | 0 | 0 | 0 | 0 | 15 | 135 | 0 | 60 | 790 | 6 | 0 | 0.0 | 0 | FW: 1st Tm All-Conf., SN: 1st Tm |
| RET | Stefan Logan | PIT | 28 | Rook | 16 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 6 | 0.0 | 0 | PFF: 2nd Tm |
| ST | Kassim Osgood | SDG | 29 | 6 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 17 | 0 | 13 | 0.0 | 0 | FW: 1st Tm All-Conf., FW: 1st Tm |
| ST | Tim Shaw | CHI | 25 | 2 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 21 | 0.0 | 0 | PFF: 1st Tm |
| ST | Heath Farwell | MIN | 28 | 4 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 0.0 | 0 | FW: 1st Tm All-Conf. |
| ST | Kroy Biermann | ATL | 24 | 1 | 16 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 38 | 5.0 | 0 | PFF: 2nd Tm |
| PK | Nate Kaeding | SDG | 27 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 1st Tm, FW: 1st Tm, SN: 2nd Tm |
| PK | David Akers | PHI | 35 | 11 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.0 | 0 | FW: 1st Tm All-Conf., AP: 2nd Tm, SN: 1st Tm |
| WR | Patrick Crayton | DAL | 30 | 5 | 16 | 6 | 0 | 0 | 0 | 0 | 0 | 4 | 28 | 0 | 37 | 622 | 5 | 0 | 0.0 | 0 | SN: 2nd Tm |
| WR | Brandon Marshall | DEN | 25 | 3 | 15 | 13 | 0 | 0 | 0 | 0 | 0 | 7 | 39 | 0 | 101 | 1120 | 10 | 0 | 0.0 | 0 | SN: 2nd Tm |
| C | Jeff Saturday | IND | 34 | 10 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.0 | 0 | SN: 2nd Tm |
| RG | Chris Snee | NYG | 27 | 5 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | SN: 2nd Tm |
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