| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 12, 2004 | W | St. Louis Rams | Arizona Cardinals | 17 | 10 | box | |
| 2 | Sun | September 19, 2004 | L | St. Louis Rams | @ | Atlanta Falcons | 17 | 34 | box |
| 3 | Sun | September 26, 2004 | L | St. Louis Rams | New Orleans Saints | 25 | 28 | box | |
| 4 | Sun | October 3, 2004 | W | St. Louis Rams | @ | San Francisco 49ers | 24 | 14 | box |
| 5 | Sun | October 10, 2004 | W | St. Louis Rams | @ | Seattle Seahawks | 33 | 27 | box |
| 6 | Mon | October 18, 2004 | W | St. Louis Rams | Tampa Bay Buccaneers | 28 | 21 | box | |
| 7 | Sun | October 24, 2004 | L | St. Louis Rams | @ | Miami Dolphins | 14 | 31 | box |
| 8 | Sun | November 7, 2004 | L | St. Louis Rams | New England Patriots | 22 | 40 | box | |
| 9 | Sun | November 14, 2004 | W | St. Louis Rams | Seattle Seahawks | 23 | 12 | box | |
| 10 | Sun | November 21, 2004 | L | St. Louis Rams | @ | Buffalo Bills | 17 | 37 | box |
| 11 | Mon | November 29, 2004 | L | St. Louis Rams | @ | Green Bay Packers | 17 | 45 | box |
| 12 | Sun | December 5, 2004 | W | St. Louis Rams | San Francisco 49ers | 16 | 6 | box | |
| 13 | Mon | December 27, 2004 | W | St. Louis Rams | Philadelphia Eagles | 20 | 7 | box | |
| 14 | Sun | January 2, 2005 | W | St. Louis Rams | New York Jets | 32 | 29 | box | |
| 15 | Sat | January 8, 2005 | W | St. Louis Rams | @ | Seattle Seahawks | 27 | 20 | box |
| 16 | Sat | January 15, 2005 | L | St. Louis Rams | @ | Atlanta Falcons | 17 | 47 | box |