| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 10, 2006 | W | St. Louis Rams | Denver Broncos | 18 | 10 | box | |
| 2 | Sun | September 17, 2006 | L | St. Louis Rams | @ | San Francisco 49ers | 13 | 20 | box |
| 3 | Sun | September 24, 2006 | W | St. Louis Rams | @ | Arizona Cardinals | 16 | 14 | box |
| 4 | Sun | October 1, 2006 | W | St. Louis Rams | Detroit Lions | 41 | 34 | box | |
| 5 | Sun | October 8, 2006 | W | St. Louis Rams | @ | Green Bay Packers | 23 | 20 | box |
| 6 | Sun | October 15, 2006 | L | St. Louis Rams | Seattle Seahawks | 28 | 30 | box | |
| 7 | Sun | October 29, 2006 | L | St. Louis Rams | @ | San Diego Chargers | 24 | 38 | box |
| 8 | Sun | November 5, 2006 | L | St. Louis Rams | Kansas City Chiefs | 17 | 31 | box | |
| 9 | Sun | November 12, 2006 | L | St. Louis Rams | @ | Seattle Seahawks | 22 | 24 | box |
| 10 | Sun | November 19, 2006 | L | St. Louis Rams | @ | Carolina Panthers | 0 | 15 | box |
| 11 | Sun | November 26, 2006 | W | St. Louis Rams | San Francisco 49ers | 20 | 17 | box | |
| 12 | Sun | December 3, 2006 | L | St. Louis Rams | Arizona Cardinals | 20 | 34 | box | |
| 13 | Mon | December 11, 2006 | L | St. Louis Rams | Chicago Bears | 27 | 42 | box | |
| 14 | Sun | December 17, 2006 | W | St. Louis Rams | @ | Oakland Raiders | 20 | 0 | box |
| 15 | Sun | December 24, 2006 | W | St. Louis Rams | Washington Redskins | 37 | 31 | box | |
| 16 | Sun | December 31, 2006 | W | St. Louis Rams | @ | Minnesota Vikings | 41 | 21 | box |