| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 11, 2005 | L | Houston Texans | @ | Buffalo Bills | 7 | 22 | box |
| 2 | Sun | September 18, 2005 | L | Houston Texans | Pittsburgh Steelers | 7 | 27 | box | |
| 3 | Sun | October 2, 2005 | L | Houston Texans | @ | Cincinnati Bengals | 10 | 16 | box |
| 4 | Sun | October 9, 2005 | L | Houston Texans | Tennessee Titans | 20 | 34 | box | |
| 5 | Sun | October 16, 2005 | L | Houston Texans | @ | Seattle Seahawks | 10 | 42 | box |
| 6 | Sun | October 23, 2005 | L | Houston Texans | Indianapolis Colts | 20 | 38 | box | |
| 7 | Sun | October 30, 2005 | W | Houston Texans | Cleveland Browns | 19 | 16 | box | |
| 8 | Sun | November 6, 2005 | L | Houston Texans | @ | Jacksonville Jaguars | 14 | 21 | box |
| 9 | Sun | November 13, 2005 | L | Houston Texans | @ | Indianapolis Colts | 17 | 31 | box |
| 10 | Sun | November 20, 2005 | L | Houston Texans | Kansas City Chiefs | 17 | 45 | box | |
| 11 | Sun | November 27, 2005 | L | Houston Texans | St. Louis Rams | 27 | 33 | box | |
| 12 | Sun | December 4, 2005 | L | Houston Texans | @ | Baltimore Ravens | 15 | 16 | box |
| 13 | Sun | December 11, 2005 | L | Houston Texans | @ | Tennessee Titans | 10 | 13 | box |
| 14 | Sun | December 18, 2005 | W | Houston Texans | Arizona Cardinals | 30 | 19 | box | |
| 15 | Sat | December 24, 2005 | L | Houston Texans | Jacksonville Jaguars | 20 | 38 | box | |
| 16 | Sun | January 1, 2006 | L | Houston Texans | @ | San Francisco 49ers | 17 | 20 | box |