| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 10, 2006 | L | Houston Texans | Philadelphia Eagles | 10 | 24 | box | |
| 2 | Sun | September 17, 2006 | L | Houston Texans | @ | Indianapolis Colts | 24 | 43 | box |
| 3 | Sun | September 24, 2006 | L | Houston Texans | Washington Redskins | 15 | 31 | box | |
| 4 | Sun | October 1, 2006 | W | Houston Texans | Miami Dolphins | 17 | 15 | box | |
| 5 | Sun | October 15, 2006 | L | Houston Texans | @ | Dallas Cowboys | 6 | 34 | box |
| 6 | Sun | October 22, 2006 | W | Houston Texans | Jacksonville Jaguars | 27 | 7 | box | |
| 7 | Sun | October 29, 2006 | L | Houston Texans | @ | Tennessee Titans | 22 | 28 | box |
| 8 | Sun | November 5, 2006 | L | Houston Texans | @ | New York Giants | 10 | 14 | box |
| 9 | Sun | November 12, 2006 | W | Houston Texans | @ | Jacksonville Jaguars | 13 | 10 | box |
| 10 | Sun | November 19, 2006 | L | Houston Texans | Buffalo Bills | 21 | 24 | box | |
| 11 | Sun | November 26, 2006 | L | Houston Texans | @ | New York Jets | 11 | 26 | box |
| 12 | Sun | December 3, 2006 | W | Houston Texans | @ | Oakland Raiders | 23 | 14 | box |
| 13 | Sun | December 10, 2006 | L | Houston Texans | Tennessee Titans | 20 | 26 | box | |
| 14 | Sun | December 17, 2006 | L | Houston Texans | @ | New England Patriots | 7 | 40 | box |
| 15 | Sun | December 24, 2006 | W | Houston Texans | Indianapolis Colts | 27 | 24 | box | |
| 16 | Sun | December 31, 2006 | W | Houston Texans | Cleveland Browns | 14 | 6 | box |