| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 11, 2005 | W | New York Giants | Arizona Cardinals | 42 | 19 | box | |
| 2 | Mon | September 19, 2005 | W | New York Giants | @ | New Orleans Saints | 27 | 10 | box |
| 3 | Sun | September 25, 2005 | L | New York Giants | @ | San Diego Chargers | 23 | 45 | box |
| 4 | Sun | October 2, 2005 | W | New York Giants | St. Louis Rams | 44 | 24 | box | |
| 5 | Sun | October 16, 2005 | L | New York Giants | @ | Dallas Cowboys | 13 | 16 | box |
| 6 | Sun | October 23, 2005 | W | New York Giants | Denver Broncos | 24 | 23 | box | |
| 7 | Sun | October 30, 2005 | W | New York Giants | Washington Redskins | 36 | 0 | box | |
| 8 | Sun | November 6, 2005 | W | New York Giants | @ | San Francisco 49ers | 24 | 6 | box |
| 9 | Sun | November 13, 2005 | L | New York Giants | Minnesota Vikings | 21 | 24 | box | |
| 10 | Sun | November 20, 2005 | W | New York Giants | Philadelphia Eagles | 27 | 17 | box | |
| 11 | Sun | November 27, 2005 | L | New York Giants | @ | Seattle Seahawks | 21 | 24 | box |
| 12 | Sun | December 4, 2005 | W | New York Giants | Dallas Cowboys | 17 | 10 | box | |
| 13 | Sun | December 11, 2005 | W | New York Giants | @ | Philadelphia Eagles | 26 | 23 | box |
| 14 | Sat | December 17, 2005 | W | New York Giants | Kansas City Chiefs | 27 | 17 | box | |
| 15 | Sat | December 24, 2005 | L | New York Giants | @ | Washington Redskins | 20 | 35 | box |
| 16 | Sat | December 31, 2005 | W | New York Giants | @ | Oakland Raiders | 30 | 21 | box |
| 17 | Sun | January 8, 2006 | L | New York Giants | Carolina Panthers | 0 | 23 | box |