| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Thu | September 4, 2008 | W | New York Giants | Washington Redskins | 16 | 7 | box | |
| 2 | Sun | September 14, 2008 | W | New York Giants | @ | St. Louis Rams | 41 | 13 | box |
| 3 | Sun | September 21, 2008 | W | New York Giants | Cincinnati Bengals | 26 | 23 | box | |
| 4 | Sun | October 5, 2008 | W | New York Giants | Seattle Seahawks | 44 | 6 | box | |
| 5 | Mon | October 13, 2008 | L | New York Giants | @ | Cleveland Browns | 14 | 35 | box |
| 6 | Sun | October 19, 2008 | W | New York Giants | San Francisco 49ers | 29 | 17 | box | |
| 7 | Sun | October 26, 2008 | W | New York Giants | @ | Pittsburgh Steelers | 21 | 14 | box |
| 8 | Sun | November 2, 2008 | W | New York Giants | Dallas Cowboys | 35 | 14 | box | |
| 9 | Sun | November 9, 2008 | W | New York Giants | @ | Philadelphia Eagles | 36 | 31 | box |
| 10 | Sun | November 16, 2008 | W | New York Giants | Baltimore Ravens | 30 | 10 | box | |
| 11 | Sun | November 23, 2008 | W | New York Giants | @ | Arizona Cardinals | 37 | 29 | box |
| 12 | Sun | November 30, 2008 | W | New York Giants | @ | Washington Redskins | 23 | 7 | box |
| 13 | Sun | December 7, 2008 | L | New York Giants | Philadelphia Eagles | 14 | 20 | box | |
| 14 | Sun | December 14, 2008 | L | New York Giants | @ | Dallas Cowboys | 8 | 20 | box |
| 15 | Sun | December 21, 2008 | W | New York Giants | Carolina Panthers | 34 | 28 | box | |
| 16 | Sun | December 28, 2008 | L | New York Giants | @ | Minnesota Vikings | 19 | 20 | box |
| 17 | Sun | January 11, 2009 | L | New York Giants | Philadelphia Eagles | 11 | 23 | box |